http://exhibits.library.stonybrook.edu/mfp/files/original/a1d81551fe70d71a4e30c15c2b67121c.pdf d4c9cea407ae14622ae8a02c9b5f55ce PDF Text Text November 7, 1969 Dr. Robert A. Turner Consulting Pharmacologist 289 Greenwich Avenue Greenwich, Connecticut 06830 Dear Dr. Turner: for your letter regarding the EEG changes during Enclosed are reprints of our clinical studies; and a pro-print of our latest report on the EEG effects of heroin and naloxone as submitted for Thank you a cycle of opiate addiction in man. publication. of greatest need in opiate addiction is an antagonist of long duration of action (24 hours minimal, 7-14 days optimal), of high potency, with minimal secondary effects, and without dependence potential. Cyclazocine is potent and of long duration but the secondary effects so common as to preclude general usage. Naloxone is potent and without secondary effects but its duration on oral use too short. We would like to see a long acting analog or form of naloxone for clinical trial. The drugs specific question is difficult to answer categorically. Subjects taking opiates during the development of dependence show EEG changes from their baseline record. When dependence is established, the BBC shows a characteristic highly synchronized, alpha dominant record. As withdrawal is instituted, the record is upset and slow waves, irregular patterns and fast frequencies become prominent only to have the record return to the alpha dominant record with an opiate. Your — If the opiate dependence is relieved, a more "normal” record will assume prominence this may be of any type, and should be distinguishable from the addicted record, in most — instances. �Dr. Turner —2- November There is, however. no single characteristic "drug" record and "clean" record, and the difforoncos are to be found in comparative or sequential recording. Thank you fbr your interest. Sincerely yours, Fink, M.D. Professor of Psychiatry Max Mszp 7, 1969 � Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Correspondence Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Correspondence to: Turner, Robert A. Type The nature or genre of the resource Text Identifier An unambiguous reference to the resource within a given context mfp-05-00-023-6-631 Date A point or period of time associated with an event in the lifecycle of the resource 1969 Creator An entity primarily responsible for making the resource <a title="Fink, Max, 1923-" href="http://id.loc.gov/authorities/names/n79039548" target="_blank">Fink, Max, 1923-</a> Subject The topic of the resource Correspondence -- Correspondence Relation A related resource The Max Fink Collection Description An account of the resource Rights Information about rights held in and over the resource <a title="IN COPYRIGHT - EDUCATIONAL USE PERMITTED" href="http://rightsstatements.org/vocab/InC-EDU/1.0/" target="_blank">IN COPYRIGHT - EDUCATIONAL USE PERMITTED</a> Source A related resource from which the described resource is derived Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York). Language A language of the resource en-US Format The file format, physical medium, or dimensions of the resource application/pdf Publisher An entity responsible for making the resource available Contributor An entity responsible for making contributions to the resource Correspondence