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                  <text>December 2, 1969
Miss Eleanor

Carroll

Executive Secretary, Review Committee

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Center for Studies of Narcotic 8 Drug Abuse
National Institute of Mental Health
5454 Wisconsin Ave.
Chevy Chase, Maryland 20015
Dear Miss

Carroll:

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We

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1.:

are pleased to report

on

the present status of the

program "Pharmacotherapy of narcotic Addiction”, MH-12567.
The project was supported for two years, ending in ﬂay 1968.
The funds were used to establish our study programs in
cyclazocine, naloxone and methadone, and particularly to
equip our EEC laboratory at Metropolitan Hospital. Based
on our initial experience we were able, and have continued
on an annual basis, to obtain support for this program

New York State ﬁarcotic Acdiction Control Commission.
important to note that the early funds from the
Commission were severely restricted as to the purposes for
which they could be expended, being limited to personal
services only. The Federal funos were instrumental in
providing the equipment, not only for the laboratory, but
for the offices and recreational needs of the study unit.

from the

It is

The staff now operates on an annual budget of more
than $220,000. inere have been many studies coopleteé,
notably in the clinical assessment of cyclazocine and its
application in the therapy of depression; the neurophysiology
of methadone, cyclazocine and heroin; the clinical use of

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tybamate, and lately our focus has been on naloxone. There
have been many publications, and copies of the more relevant
are enclosed. Support of the area has been cited in each.

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Based on these experiences, we are convinced that the
antagonist therapy for opiate dependence is feasible and safe;
have recommended that naloxone in a silastic vehicle provides
the best single hope for this problem today; and have defined
some of the neurophysiological parameters of opiate dependence
and the antagonists .

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Miss

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Carroll

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December 2, 1969

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are also pleased to report that these experiences have
given us the basis for our interest in studies of cannabis, and
led to our preposal of a cannabis study program at the New York
Medical College (MH-18245) and one in Athens with Professors
Hires and Stefanie.
We

I

useful.

trust these

comments

are helpful, and the enclosed reports
Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry

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              <text>Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York).</text>
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