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                  <text>December 3, 1968
Dr. Peter E. Siegler, M.D.
The National Drug Company
Haines and McCallum Streets

Philadelphia, Pennstlvania
Dear Dr.

19144

Siegler:

Enclosed

is

a

draft protocol for the study of aletamine.

It is divided into three parts,

which are successive

approximations of the analysis of the problem.

initial

trials are designed to test the dose and
time relations of a single dose as it affects the EEG profile.
These trials provide the basis for the definitive classification
trials which are comparative with knoun standards. As soon as
the classification is defined with surety, a clinical study can
he designed and undertaken in the appropriate papulation.
The

EEG

While this procedure may be greater than the conventional
open or double-blind clinical trial, it has some distinct

advantages in providing the conventional data as well as the

theoretically significant neurophysiological profile.
I will be pleased to have you visit once again to discuss
these proposals in greater detail and wish to thank you for the
opportunity to read this interesting material.
Sincerely yoers,
Fink. M.D.
Professor of Psychiatry
Max

Mfzkp

�</text>
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              <text>Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York).</text>
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