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                  <text>,
MW

1‘-

December 15, 1969
Dr. Harold L. Williams

Department of Psychiatry
University of Oklahoma.Hedical Center
800 Northeast 13th Street

Oklahoma

"is.

swim-v,

~.~

Oklahoma 73104

Dear Hal,

..-

-.‘mv-r

City,

It

pleasure to review the paper "A longitudinal study
of the quantitated base~line electroencephalograms in reformatory
inmates and normal volunteers” by Goldstein and Hopkins. It is
an essay on the variability of the amplitude measure of the 886
in normal subjects and suggests that the individual variability
of the measure is so great as to make useless single baseline
recordings; but, also that the group data is such that averages
of subjects, even single recordings, are representative of the
total pepulation. The observations are presented with statistical
the
support and the conclusions are reasonable and are based ondone
be
should
of
that
the
kind
a
study
data presented. It is
in psychophysiology, and presents the basis fer the applications
that will be made by others. I believe it should be published,
with some clarifications by the authors.
1.

was a

The females

include three

who used

anti-ovulatory drugs.

others, presumably went through their menstrual cycle. The
records from two different laboratories, those of Ulett and

The

Margerison, indicate

the menstrual cycle.

that systematic changes in
The

EEG

authors should indicate

affected their measures (Pg. 5).

occur during

how

this variability

important element of variability in the normal EEG is the
state of alertness. The authors fail to define the measures they
used to maintain alertness, and yet state (pg. 7—8) that they
discarded those samples that indicated drowsiness. Since a
principal sign of drowsiness is a reduction in amplitudes and
an increase in frequency variability, perhaps this procedure
(artefact control) provided the basis for the variability reported.
The procedure used for artefacting records must be spelled out,
and if unsatisfactory, would be the principal basis for rejection
of the study.
An

�/
«aw-«qu

.._,

--w-:vv

wet—"2

'Yﬁ‘ﬂuwu

December 15. 1969

~2-

Dr. Williams

interesting observation, that
EEG in systematic ways for
the
situational anxiety altered
the subjects under long term observation. This is an
introduction to a study and may be omitted here as an unproven
The authors suggest an

assertion (pg. 13-14).

The contention that anxiety is a feature of schizophrenia
is also an interesting contention but unrelated to the results
of this methodological study. The suggestions on page 16, 18
are assertions that require study and are best deleted for this
report. Much of the discussion pp. 16—19 is not relevant
to the normative aspects of the study, reflecting the authors
extensive interest, and could be deleted here.
Table V is interesting. The authors know the literature
on the 'first night effect' in sleep recording and the sequence
effects in drug studies. yet they seem surprised at the observation
here. Is this observation unrelated to the ones reported earlier?
and

Such normative data provides the

this report warrants publication.

the data for

basis for further studies

me.

My

questions would clarify

Sincerely yours,
”ax Fink,

rat-D.

Professor of Psychiatry

Mszp

�</text>
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              <text>1969 </text>
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              <text>&lt;a title="Fink, Max, 1923-" href="http://id.loc.gov/authorities/names/n79039548" target="_blank"&gt;Fink, Max, 1923-&lt;/a&gt;</text>
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              <text>Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York).</text>
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