http://exhibits.library.stonybrook.edu/mfp/files/original/917c7658098839f5078fdeb8097c1080.pdf d3e673159593810e72e2f48d8870f943 PDF Text Text v “x ~'1L'erwi-lwl~."r" - uv-W-xaw, - va-w IK‘II-wtv‘l'n .-wa-r=ww-uw—wmmurxar W > ,' Java-v: ~ . '. w ”.37" _ 'I'Iwm'xa"1- 1 .Wu nay-rur- October 28, 1969 Editor England Journal of Medicine lO‘Shettuck Street Boston, Massachusetts 02115 New Dear Sir: Pitts and McClure (N.£ng.louh.Mcd., 1967, 311; 1329-1336) reported that intravenously administered sodium lactate precipitated a severe anxiety attack in 93% of individuals diagnosed as anxiety neurotics but in only 20% of normal controls. They were also able to minimize the effects of lactate by intravenous calcium. undertook a replication of this study, using their techniques and, with their couperation, their lactate solutions. In five patients with lactate, each patient covelopcd acute anxiety between the 3th to 12th minute of infusion, peaked at 15 minutes, and remained seVero for 15 to 30 minutes. Each patient experienced "after effects” of irritability, dysphoria, tension, fatigue and weakness For 2~7 days. We to lactate/calcium was similar to lactate alone, but significantly‘less in intensity and duration; and there were no “after-effects”. There was no patient response to dextrose/saline. The response In feur control subjects, the response to lactate was characterized by tachycardia and restlessness, but without anxiety in 5 subjects, nor ”after effects“ in four. Anxiety was elicited in one control. The controls become drowsy and bored with lactate/calcium and éextrose/saline. Ac with Pitts able to correctly and McClure, a “blind” investigator was name 25/27 solutions (92.5%); the patients 13/15 solutions (87%); and the controls 6/12 solutions (50%). In concurrent scalp recorded cloctroencephalograms, we observed changes with lactate in the patients, not shared by the controls or by dextrose/saline and lactate/calcium solutions. The EEG exhibited increased beta and decreased alpha abundances end a decreased alpha amelitude. These findings are consistent with the EEG changes usually seen in anxiety states. �Editor, by New Eng. J. -2- Med. lactate are well summarized would also add to their formulations these observations have two interesting applications. A Hypotheses relating anxiety and Pitts that and McClure. We lactate tolerance test provides Twwflu. October 28, 1969 a group of mentally ill with an common means of identifying characteristics of anxiety objective neurosis, for both therapeutic and prognostic trials. The antagonism of calcium to lactate precipitated anxiety and its successful therapeutic trial (Pitts, personal communication) suggests that other anti-anxiety agents may be tested using ' u: - this model. ‘ Sincerely yours, .~. 3.: ”WW uwna-w P".- 5“an Fink , :‘I o D e 'wzawr-mxz‘ . .mflm’mflP'W‘ Michael Alan Taylor, M.D. Jan Volavka, MF :kp M.D. � Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Correspondence Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Correspondence to: New England Journal of Medicine Type The nature or genre of the resource Text Identifier An unambiguous reference to the resource within a given context mfp-05-00-023-5-444 Date A point or period of time associated with an event in the lifecycle of the resource 1969 Creator An entity primarily responsible for making the resource <a title="Fink, Max, 1923-" href="http://id.loc.gov/authorities/names/n79039548" target="_blank">Fink, Max, 1923-</a> Subject The topic of the resource Correspondence -- Correspondence Relation A related resource The Max Fink Collection Description An account of the resource Rights Information about rights held in and over the resource <a title="IN COPYRIGHT - EDUCATIONAL USE PERMITTED" href="http://rightsstatements.org/vocab/InC-EDU/1.0/" target="_blank">IN COPYRIGHT - EDUCATIONAL USE PERMITTED</a> Source A related resource from which the described resource is derived Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York). Language A language of the resource en-US Format The file format, physical medium, or dimensions of the resource application/pdf Publisher An entity responsible for making the resource available Contributor An entity responsible for making contributions to the resource Correspondence