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July 5, i969

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Dear John,

—rv'."rz-.-.4-'

"H'an-ava'r

The holiday has given me a chance To catch up on my reading,
have Jud? ro-raad your ”A Porspecfiva on Heroin”. if is a fine
article, and gives a clear image of fho hisfory loading +0 our present
inadequafe legal siluafion. i was remindbd of an infervleu i had in
May wifh fho commllloo of fho New York Academy of Medicine, ro—
assessing for fhe n'fh limo The need for changes in The medical
lroafmen? of oddicflon. i iold Them of our experiences with methadone
and cyciazocine, and whon i oxprossad some enthusiasm for +hoso
pharmacological froaimonis was asked if i fhoughl They were ofhicai.
The mean age of fho commlfloe members was suroiy 75 yoors. i avail

and

«

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fhoir reporl wilh

some

anxiety.

also read your AMA reporr and if is mos? sfraighf—forwnrd.
will probably be disregarded by everyone in ihe legal profession,
bu? for us if will remain an imporfanf reference. Brofmon and Freedman
both expressed approval also.
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should have moved +0 your

new Doparimeni, and
be as produclivo there as you have
in The slain programs. Sidnoy has found a new home and moved in lasl
week (lil Ferry Slroof, Barringlon, R.i.i, and is raking his family lo
Soufh Africa for a visif fhls monlh. My son, Jonoihan, has graduofod
high school and will a++ond Colby Collage in Manna lhis fail. Mnrfha
has enjoyed her Teaching in Gran? Neck very much (quite a difference from
fhe For? Washingfon school) and looks forward lo continuing. For fho
summer she is faking The girls on fhoir firsf European frip, on a
By now, you

l

lrusf Thai

you

will continue

To

mini~grand Tour.

Our own work is progressing slowly. The molhodone program
confinuos lo be succossful; cyclazocino also, alfhough more care mus?
be exercised in froafing fho paflonfs. We havo looked of fhe problem
of dofoxifylng Those parienld on moihadono for more fhan 2 years, and
who may be making a good adjusfmeny. We Tried To do fhis ulfh The
agroemonl of fhe subjecls and fho sfoff, and failed. We aro now
fransforring pafienfs from methadone fo cyclazocino (blind) and have
begun to decrease the cyclazocino donage. So for, no wllhdrawai and

no

difficulfies wifh anyone.

zv-l

Naloxono confinues To be a difficult problem. ifs durallon
of aciion of 2.4 ems/day is about 24 hours, bu? lho company provides

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spun-um.

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tablets onlyan and have you ever tried to get addicts to take
24530 tablets at once ? daily 7 voluntarily 7 7 To get around this
problem we are trying to develop a long acting form of naloxbne, using
the principle of embedding in a sliastic vehicle. We have asked NiMH
(Sidney Cohen) for a contract to proceed in this development, but he
seems less enthusiastic than we would like.
iOO mg

research.

Our

principal effort for the present is in marijuana

to our staff, and
visit to Greece, l visited
the laboratories of Konstantin Mirase- found them ever so much better
than
anticipated, with fine chemistry facilities, excellent
Al

he begins in

Freedman has appointed Martin Keeler

mid-July.

On

a

recent

i

neurophysiological equipment (under the direction of Dr. Stefanie,
an NIH trainee) and his own garden for growing cannabis. Dr. Miras
is an expert in the plant growth, constituents, etc., and any project
that works with his help, must be better than the trash being published
today. (Have you seen the recent article on driving comparing 2

cigarettes of

NlMH marijuana with 0.l mgz blood label alcohol ?)
desire is to formulate a study program in Athens and Al and
have proposed this to NlMH (again, Sid Cohen) as a contract. Of
course, we are now anxious to undertake some extensive, long term
studies here to assess the neurOphysioiogic, behavioral and

Our

l

psychologic

effects of chronic marijuana use.

it

has been a busy year, for in addition to the narcotic
have continued studies in ECT, EEG and even in schizophrenia
and anxiety. Any chance of a visit the next time you are in New York ?
program!,

i

One

last

comment.

i

attended

a

special open session

on

marijuana held in New York in June under the direction of Representative
Koch (U.S. Congress). Brlii, Fort, Cohen held the MD lids and three
lawyers the legal side. My first exposure to such sessoons. Lots of
name calling, arguments ad hominem, and most impressive, the repeated
plea for more studies. Even the young people asked for more data, and only
Henry Brill was sure that the drug was harmful, regardless of the data.
it was a wild session, and Representative Koch expects to propose a
bill to set up a study commission on cannabis (like a President's
Commission).

Keep up the good work, and many thanks for the fine articles.
have not obtained permission for our study of methadone in
psychosis, but it is less important now that l have other interests,

We

still

although

it

My

should be done.

best regards to Deena.
Sincerely yours,
Max

Fink,

M.D.

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