http://exhibits.library.stonybrook.edu/mfp/files/original/66157bf92e45ff8682685efef98cde2c.pdf 51b343c2a736d887f1b0b1b78e36d919 PDF Text Text August 6, 1968 Dr. Gaston-Germain Trigos “yeth Laboratories Box 8299 Philadelphia, Pennsylvania 19101 Dear Dr. Trigos: It was a pleasure to discuss studies of WY 3263 and WY 4036. have had the opportunity 00 review the data submitted and believe we can contribute to your study program. We WY These 4036. initial reports of this novel compound report anti-anxiety properties. Most unusual is the report of amnesic properties in patients. I reviewed the available EEG data, seeking a better definition and anti-convulsant its neurOphysiology. Motor activity in mice was suppressed, with 4036 being 100-200 x as effective as chlordiazepoxide. The EEG activity in cats showed a "decreased frequency and further spindling" at intravenous doses of 1 mg/kg to 4 mg/kg. It is reported an of WY exceptional anticonvulsant, particularly against metrszole. of The clinical data reports ataxia and sedation during administration ng/day oral, and nervousness, insomnia, diarrhea or constipation two to three days after cessation of NY 4036. 5—10 Two studies are suggested in the pppulation available in these laboratories. l. EEG Profile. As indicated, we find the EEG profile in volunteers, supported by similar data in patients useful in classifying new psychoactive drugs, and identifying target populations. If a parenteral form of WY 4036 is available, an EEG profile study can be done rapidly, and a suggested protocol is enclosed. If can be done but only an oral form is available, a similar study extensive material and allonger protocol indicates the differences in requires more it The period of study. design in the supplement. �-2~ Dr. Trigos WY 2. Clinical trial. The anti-anxiety activity of 4036 should preperly be tested in a wide variety of anxiety subjects. Our ongoing 4036 studies of anti-anxiety agents in a clinic population permit the introduction of in either an open study or a random comparison with mental health WY August 6, 1968 chlordiazepoxide (our present standard). I would also suggest that a study of the sedative effects of WY 4036, especially its effects on the sleep - EEG ("sleep~prints") be considered. The data cannot be collected in my laboratories, but we are uniquely equipped to analyze data recorded carefully elsewhere. The data can be collected in collaborating laboratories, and if this is of interest, I will be glad to provide the ”mm ”mal75 details. WY 3263. The extensive trials already completed are clear and the new efforts that may be necessary for a better delineation of clinical applications may come best from the extensive clinical crisis”Vhen;gwb‘ prindole is released. The data does not include reports of EEG examinations. These would be useful to define the neurophysiologic basis of the clinical response. In the facecftthe extensive clinical data, perhaps such data would only satisfy our scientific fancy. An EEG yet be useful in completing the be assessed in a fashion similar to so, can profile study submission, and if may that suggested in the protocol for WY 4036. protocols are enclosed, for an EEG profile analysis and a clinical trial of WY 4036. Protocols for a sleep-print EEG study of WY 4036 and an EEG profile of WY 3263 will be provided. Two Thank you material. for the opportunity of reading this interesting Sincerely yours, Fink, M.D. Professor of Psychiatry Max � Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. 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