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                  <text>August

ll.

l969

Dr. Allen P. Burger

Associate Director
Department of Clinical Research
Chas. Pfizer a 60.. Inc.
Groton. Connecticut 06340
Dear Dr. Burger:

for thiothixene oral concentrate
considerable interest. I have reviewed the
clinical data and find that the data is consistent with the
following conclusions:
The

NBA

was read with

summary volume

l. Thiothixene concentrate is an active psychoactive
the patients exhibiting decreased psychotic symptoms.
parkinsonism and sedation. These features were reported in all
studies in which daily doses above 20 mg/day were used. The
agent

«-

symptoms were equivocal

at lower levels.

2. The two studies which compared the clinical
efficacy of capsules thiothixene and oral concentrate reported
similar clinical effects at comparable dosages.

a

-

3. Tables of the reported secondary effects of both
patterns of

forms (capsules and oral concentrate) show the same
effects with a similar incidence.

Furthermore. the dosages. clinical and secondary effects of
the reports of oral concentrate are similar to our own studies of
thiothixene in capsules reported in l967. and I would have no
hesitancy in undertaking clinical trials of the concentrate
in treating schizophrenia at dosages comparable to thiothixene
capsu es.

-

Sincerely yours.
Fink. M.D.
Professor of Psychiatry

Max

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              <text>1969 </text>
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