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                  <text>August 25. 1969
Dr. Wilma Harrison
Geigy Pharmaceuticals
Ardsley, New York
Dear Dr. Harrison:
Our initial trials with GP 41,299 have progressed well.
In 15 trisls in nor-a1 volunteers, we have used dosages of
25 to 200 mg. The observation period of EEG and behavior
has been 1 1/2 hours. we have also obtained the subject's
reports of the succeeding lé—Zh hours.
and

for

day.

behavioral effects of sedation, drowsiness
100 33. These symptoms persist
hours. the subjects reporting sleeping late the next

we have observed

lsssitude at dosages over

many

The EEG changes

are defined as increased theta and some
and a decrease in amplitudes.

delta; reduced beta activity;

These preliminary data are insufficient to classify 6? 41,299
but do provide the basis for the second phase study as outlined
in our protocol. Before undertaking this study. however, I an
anxious to check s few records at a longer time period (4 hours).
As soon as these trials are completed, I will send you a revised
part 2 of the protocol.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Mex

Hrzkp

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              <text>Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York).</text>
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