http://exhibits.library.stonybrook.edu/mfp/files/original/c0abcdd34082d41ff68afebd1838dce7.pdf 5bfcff326bc8904f46e8021ab9ce6a0d PDF Text Text mwvsr-kuw—wfl 7...“, v-v—nv -.-r,,~.wv‘,....._..v.r,.... . .,., August 26, 1969 Mr. Herman Heisman Hoffman La Roche. Inc. Nutley, New Jersey Dear Mr. Heisman: a pleasure to have you and Mr. Billig visit my laboratory last week. The questions you raised, whether objective drug specific patterns can be defined for Librium is challenging. Specifically. you asked whether neurophysiologic It was indices could distinguish Librium (in therapeutic dosages) from barbiturates (e. phenobarbital)? Your reference to .. define su to failures patterns in prior animal studies suggests the difficulty of the problem. There is some evidence that such a discrimination feasible through quantitative EEG measures. may be quantitative EEG studies of anesthetics, Belleville in specific responses for different anesthetic Studies of amobarbital by the barbiturates agents, including 1. 1n 1956 showed frequency Shagass and of pentothal by Goldman and ltil showed frequency specific curves for these compounds in mentally ill subjects. 2. Recent quantitative studies of pentothal developed mathematical a expression for the EEG response (see enclosed). This curve differed in patients receiving a phenothiazine from those receiving placebo, suggesting that drug interaction in the CNS may have altered the parameters of the expression. profiles of Librium and Valium are similar In our study of diazepam, imipramine and placebo. our techniques classified diazepam. and this pattern dhffered from imipramine. 3. The EEG to barbiturates. techniques used in these studies represent the available best today. In addition, instead of using a period model. the more refined power spectrum reduction data analysis could be applied for greater resolution. Using power spectrum as a back-up, I believe it should be possible to define EEG profiles in volunteers. This could be attempted with either oral or intravenous preparations. Two courses are suggested. The EEG �-2- Mr. Heisman l. August 26, 1969 Oral study. In an oral study, the changes in EEG may be defined during l~3 hours post-drug using a period~analysis model.- The first step would be a definition of “equivalent" oral dosages of chlordiazepoxide and a barbiturate.x The equivalence may be defined from the literature or in a pilot byu33havioral criteria, either s . In a definitive study. volunteers would return for 3-4 sessions. to receive in random sequence chlordiazepoxide placebo - barbiturate; and a second dose of chlordiazepoxide or barbiturate. Data analysis would follow established univariate (t-tests) for each variable at different times; or, a discriminant fonction approach for split samoles ~ using l/2 the sample to define the beta-weights and verification in the second half of the sample. 2. Intravenous study. These techniques are more adequately tested. The mathematical expression for pentothal has already been defined. study of the changes in volunteers receiving intravenous would allow verification of the pentothal curve. and a statement of the parameters of the A EEG pentothal, chlordiazepoxide or saline chlordiazepoxide effect. Either study could later this fall. The be undertaken in these laboratories questions you raise are of theoretic as well as practical significance. studies have been undertaken. In knowledge, no such because EEG quantitative To my part. techniques before 1963 were too inexact and unstable to be useful for the fine discriminations required by your question. Thank you for the opportunity to review this question. Sincerely yours . Fink, H.D. Professor of Psychiatry Max Mszp enc. � Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Correspondence Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Correspondence to: Weisman, Herman S. Type The nature or genre of the resource Text Identifier An unambiguous reference to the resource within a given context mfp-05-00-023-4-326 Date A point or period of time associated with an event in the lifecycle of the resource 1969 Creator An entity primarily responsible for making the resource <a title="Fink, Max, 1923-" href="http://id.loc.gov/authorities/names/n79039548" target="_blank">Fink, Max, 1923-</a> Subject The topic of the resource Correspondence -- Correspondence Relation A related resource The Max Fink Collection Description An account of the resource Rights Information about rights held in and over the resource <a title="IN COPYRIGHT - EDUCATIONAL USE PERMITTED" href="http://rightsstatements.org/vocab/InC-EDU/1.0/" target="_blank">IN COPYRIGHT - EDUCATIONAL USE PERMITTED</a> Source A related resource from which the described resource is derived Special Collections and University Archives, University Libraries. 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