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                  <text>August 28, 1969
Miss Eleanor E.

Carroll

Acting Chief
Center for Studies of Narcotic
and Drug Abuse
National Institute of Mental Health
5&amp;5“ Wisconsin Avenue
Chevy Chase, Maryland 20015

Carroll:

Dear Miss

questions of August 25 are most interesting, and
I can answer immediately.
I use cannabis as the general term for the plant species
and products to include marijuana, hashish, and themr extracts,
as the cannabinols. In a broad sense, the word can also "cover"
the synthesized tetrahydrocannabinols, if we assume these to be
related to the active principle of the plant.
1. Strength of cannabis. Two problems are involved ~
the cannabis used by the subjects for years, and their present
samples. Dr. Miras has assayed samples for some years now add
we will depend on his estimates of the quality available
of the subject's
historically. I expect that direct doassays know
be
done. I
not
present materials will
if a history of
cannabis quality during these decades can be compiled, but we
can attempt this. I will being your question to Dr. Miras'
some

Your

attention.

Definition of "Chronic". In Dr. Miras classification,
we are focussing on the B, 8-0 and C groups. The initial step in
the project is to identify the population and assess their reports
of cannabis use. The subjects introduced to me claimed daily
hashish use since their early adulthood, approximately 20-30
years. We will examine as many as we can and report their statements. "Chronic" will be defined by these records.
3. Sample size. Dr. Miras speaks of 200-300/subjects
in Athens. We would survey as many as we can, and study in
2.

detail 30-40.

�Miss

Carroll

August 28, 1969

~2—

Drug use forms. I will write to Dr. Miras
requesting a copycf his form. The DCMH form and our cannabis
inventory (derived from Haertzen) are enclosed.
Dr. Miras' classification does have "overlap", and he
emphasizes the fluidity of subject's use, allowing him to
classify subjects as A/B or B/C. Perhaps we will be able
to define these classes more satisfactorily. I expect it
to be difficult since it is likely that the reports by each
subject will fluctuate widely depending on their trust in us.
Our experience with Opiate addicts may be useful - for we
usually disregard the reports given initially, and depend

u.

more on

their later reports.
5.

Sibs and family members.

Yes.

Vilunteers. We wish to bring some subjects into
the hospital for testing; allow them to smoke their products;
and examine them for 2h~48 hours (or longer) thereafter. To
induce their cooperation, we will pay them for lost income pﬁus
a bonus for volunteering (plus, on occasion, money to buy their
hashish in quantity sufficient for trials and for assay). If
we get 30 subjects, it averages $100/subJect. This may be too
high, but we can report our exact costs and return any balance
6.

of the requested amount.

"Hashish'. In my initial interviews, I was
men claimed nbt to use alcohol or opiates.
We are interested in drug "associations" and
synergistic uses and will inquire, not only for their present use, but their
historical use as well.
8. Anthropological, Sociological Consultation.
This is a defect in the present proposal which may be remedied.
I am asking Dr. Feldstein to make the first examinations, and
he is aware of this issue. I have written to Dr. Miras about
this question, and he has yet to answer. You will note I
request funds for 2 consultants, and have named only one
(A. M. Freedman). I would like to consider, once our initial
data is collected, to ask Richard Brotman of the New York
Medical College to assist us.
Some forms are enclosed. The rest will follow as received.
Sincerely yours,
7.

impressed that the

Fink, M.D.
Professor of Psychiatry

'Max

Mszp

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              <text>Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York).</text>
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