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                  <text>May

26, l969

Dr. Jerome Levlne

PsychOphermacology Research Branch
NlNH

5454 Wisconsin Ave.

Chevy Chase, Maryland

Dear

Jerry,

Since our discussion of The chlorpromezlne blood levels
and
measures, l have had an opportunlfy +0 discuss #he
proposal shortly wlfh Sam Gershon and at greefer length wllh
Dr. Julius Korein. From befh, I found the expecfaflon The?
the bgggd levels should correlate wlfh The EEG signals. This
Ian ¥9§8$8 unfounded.
8§Bec
EEG

sfudles of biodd levels and some
measure of brain function, and in each fhe correlaflons are
poor. This is usually "explalhéﬁ‘68i°+hﬁlpbaeiﬂdgohefhe
m“'Kb‘l'here have been many

in sﬂﬁdlbs El
barrier'.
if is possible to malnfeln

Héﬁfofhal anasfhesla,
a steady blood level,
EEG
shows specific sequences of changes which
and yet the
are correlafed wllh The subjecf's aneslhellc slefe and nof
with The blood level (raulconealumbsmelzm; 15: 3m, I952).
In a
of cﬂéggdlazepoxlde Whlfmen and Sfern found no
sludé r5981»
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Dr. Jerome Levlne

-2—

May

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w

26, I969

I would be
pleased to parflclpate ln anofher study relating
blood levels wlfh behavlor and wlth other quanflfaflve measures,
and surely we can provlde The EEG measures. l anflclpafe That

expecfatlons

The

may

be

unfulfllled for blologlcal reasons (If

pas? experlence ls susfalned), and any relaflons wlll have *0
be leased out mos?

carefully.

'EEG measures were provlded
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