http://exhibits.library.stonybrook.edu/mfp/files/original/1a9bef50f3603a44b1eae50bdd2f26c6.pdf c5801448b43820f9fa0c41b9b8decdbb PDF Text Text May 28, 1959 Dr. Norman E. Pitts. Director Department of Clinical Research Pfizer Chen. & 00.. Inc. Groton. Connecticut 06340 Dear Harman, on I have rend the Hurstorio. Msggini and Hurri report Subjects" "Effects of P-3693A on the Night Sleep of Depressed with much interest, having heard this report in Spain but failing it all to grasp the significance at that time. I appreciate The report doxepin. the more for having our own experience with of sleep with recent reports is good, and the data is consistent doxepin. with EEG in depression and with out experience Despite the repetitious style, the authors describe disordered frequent awakenings sleep among their depressive subjects ~ with A as the principal effects. 3 and and decrease in percent tine stages with high dosage doxepin, within one week there is a reduction in awakenings and an increase in deep sleep. The increase in REM~tine is unusual, though probsbly drug related. These changes appear drug related. The adaptation after 2 weeks is a possible problem; we would have wished some data in weeks 4 or 5 of treatment. discussion in relevant. The authore‘ distinctions for doxepin from other drugs, while possibly true, is interesting and data reportable, but I would hove gishsdggﬁerg ggrgpggrgzsecure be few to for antidepressants and BOT. “wheaggporgopsre too definite, although the results parallel the findinge reported on here for doxepin. ﬁhﬁkb The impressed by the dasgycoadyxanAAggsk that the dosage be confirmed (it scene high); that if any similar data for week should be reviewed; and what subsequent a orwi ﬁlelxléﬂahday studies (with dorspin or other psychoactive agents) have the I am it ant-hm W Amarmmywqiommﬁm Enema-(memes ORL tehorra° Lﬂﬁﬂy hon 5r* grate he: of .cenmawyith esm- «memmem berrcnce In the qcxnbrn cpnubrapsmipnnprn nesg' gps qece or I pens neceerq 1:1}.3 moron on In ‘nﬁéw to; eanrnﬁ me 3 CL I¢~3Qg one my}? comhyere tyre behsr’ —3~ AU§Cﬁ MITI pe acorn} 59% 38’ 1896 �wn—r~',wy y‘aa—M “mg-W . war-u: — *- ,,m~..w-w-..mwr—.w.v,n— _ Dr. Pitts Thank you in our reports. -2for sending no this paper, 28, 1969 May which will bu useful I have received Itil'n notes chnupununuugbnghﬁp week. on CP 14-368 and will complete The data of 8 patients in the doxapin ww- WWEW133‘ MW s In: 0:"? “MﬁimmeMFm acnqxea (arty qoxnbrn o: ocpsz balcposccxas pans cos Enema-wanna. 1! outgoi- huh . 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Extra; 9 co°’ Inc* nsboccmeuc o; cyrorcwr guesszcy Dc. gall?” 3- 51cco’ urnsccon Nth 58' I693 � Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Correspondence Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Correspondence to: Pitts, Norman Type The nature or genre of the resource Text Identifier An unambiguous reference to the resource within a given context mfp-05-00-023-3-268 Date A point or period of time associated with an event in the lifecycle of the resource 1969 Creator An entity primarily responsible for making the resource <a title="Fink, Max, 1923-" href="http://id.loc.gov/authorities/names/n79039548" target="_blank">Fink, Max, 1923-</a> Subject The topic of the resource Correspondence -- Correspondence Relation A related resource The Max Fink Collection Description An account of the resource Rights Information about rights held in and over the resource <a title="IN COPYRIGHT - EDUCATIONAL USE PERMITTED" href="http://rightsstatements.org/vocab/InC-EDU/1.0/" target="_blank">IN COPYRIGHT - EDUCATIONAL USE PERMITTED</a> Source A related resource from which the described resource is derived Special Collections and University Archives, University Libraries. 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