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                  <text>r‘

WWW-r

WW

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- ”-rv‘r'ni-‘Il'rv'

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T'w-va-rmx‘y,

.,

..

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,N, ,.

,

March l3, l969

Dr. Hudgon Hoagiand
222 Maple Avenue
Shrewsbury, MassachuseTTs 0l545
Dear Hudson,
Thank you

The manuscrist abouT sex—raTio and
your commenTs. The daTa are small and

for reading

schizophrenia and for
require furTher duplicaTion and eiaboraTion and we are proceeding
wiTh Two proJecTs - one To repiicaTe The flrsT sTudy and one
To predicT The sex of

picTure.

offspring

based upon The maTernai

clinical

ThaT The preposed hormonal mechanism is speculaTive.
ThaT
The
clinical Trials ciTed in The manuscrist auggesT
However,
The adminisTraTion of TesTosTerone or progesTerone can enhance The
TherapeuTic effecT and decrease The relapse raTe from ECT. Torghele's
successful TesTosTerone-ECT TreaTmenT of chronic, Therapy—reslsTanT
schizophrenic women furTher suggesTs ThaT These hormones may
affecT The psychoTic process.
I

agree

difference in produchon of TesTosTerone and progesTerone
and female feTuses ls a crucial quesTion. WheTher
male
beTween
The difference ls in amounTs or in funchonal achvlTy of feTal
TesTosTerone or in The feTal meTabolism of placenTal progesTins
To androgenic forms is noT yeT known, buT such a difference
would indeed sTrengThen The argumenT. The possibiilTy ThaT These
hormones may affecT The chromosonal DNA codons in The defecTive
parTiculariy inTeresTing,
offspring (all defecTs were in The CNS) isinTellecTuai
funcTion
of
increased
DalTon's
reporTs
in View of
of
progesTins
dosages
received
high
moThers
in children whose
in The early pre-parTum period.
The

The quesTions you

raise should

sTimuIaTe Taylor and Levine

in furTher invesTigaTion and They and l Thank you for your Time
and commenTs. They will be presenTing This daTa aT The SocieTy

of Biological PsychlaTry in
This furTher aT ThaT Time.

May

and

i

look forward To discussing

Sincerely yours,
Max

Fink,

M.D.

Professor of PsychiaTry

Mszp

wwmm,

-

van-'ervv

414.”

�</text>
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              <text>Correspondence to: Hoagland, Hudson</text>
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              <text>1969 </text>
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              <text>Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York).</text>
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