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                  <text>April 5,

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1969

Dear Leo,

I have just read your review of the clinical status of
psychotherapeutic drugs in Clinical Pharmncolqu and Tﬂerapeutiua with
great interest and wish to congratulate you on writing an aminently
readabla and useful report. I would apptactate a reprint whan thesa
are available, but will probably gore: the report for the students, since
most of the opiniona are similar to thase which I hava preaaated and
hold.
Taste nra a few cmmmenta that I.would like to ahara
with you. Recently, with regard to the'anti~anxiety druga, um
reviewnd our clinical recordﬁ and found that tha results observed
for chlozdinzapoxide were vary gaod during the early waaks of treatment,
but the response became prograasively less in time. we examined the
data for the possible development of tolerance ané in some reeant cases
we have athieved better results by interrupting treatment at frequent
intervals. In our studiaa of high acne tybamate in tha treatment of
opiate addiction, we were aatonlshed at the rapid rate which the
patients dgveloped tolerance to the aeprasaﬁve an&lt;§sedat1ng effects
of the dosages we uaad ( ti 12 Gms.

)

In the notes on tha traatment of psychosis, why was no
mention made of the possibla utility of long~acc1ng fluphanazine ?
Your choice of thiariduaina as can of the drugs to be
included in one' a armamentariua shows how brave ycu reall.y are, for the
EKG changes which vs found so prominant have haen sufficient t0 deter
me from racommending it for just each purposes.

Again,

my

congratulations on a reviaw well dona.
Sincerely yours,
Max

Fink,

M.D

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              <text>1969 </text>
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              <text>Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York).</text>
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