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                  <text>April 21,
Dr. Torso

1969

Itil

Profoaaor of Psychiatry
Missouri Inatltute of Psychiatry
St. Louis, Missouri

Ref:

CP~

l&amp;,368

Dear Torso,

For some time I havo expressed tho desire to examlno
potential psychoactive compound in the EEG analytic scroen,
without tho utual animal or clinical olues, which could influence
our EEG evaluations. Dre. Betas: and Pitts of Pfizat Medical Research
Laboratorlen havo mods such a otudy possible. and I am writing to ask
your assistance.
-

a naval

‘

Enclosed is a cepy of tho available animal and clinical
pharmacology data, an augplitd by Dr. Berger. 1 would be grateful
for your reviuw of this notorial and your toaponse to the following
question:, which I propose to use in formulating a daftnitlvo pilot
A: I would like to start with singlc, oral dosagao in young
study.
(21»35 yearn) male voluntoero, the questions aro:

what dosage should be tasted
what incromonts should be tested ?

initially

?

If

no

effect,

‘rr'r‘n

~

tear.

a

egfocts

7

At what time
What

~svr¢x,ys;rﬂf”vrt=v'm,~

-'

é

in the

reviaw of the data

intorvala can
maximum dose

7

-'

.

*

r-‘u.~"

«damp

a;
~19

anticipato clinical and/or

that should

EEG

be toatod beforc your

effects should ho tested for most carefully 7
secondary effects are experienced, what are the prohibited

what secondary

Aneuming some

antagonists? the preferrod,

”

wt

What

if

are the primary

known ?
EEG

leads to be examined?

Any behaviorol questions that may be anticipated in addition
the
one: included in the Clyde Mood Scale, which we have used in
to
these studies to date ?

�'-

x

{A

1:11

0

I

I

a

o

I

o

0

2

a

I

O

.

.

.

.

.

April 21,

I would like to begin these studieq about June 1, and would
appreciate the opportunity to discuss this with you beforo the APA

meetings in May.
Many

thanks, and

“\i.
"\x

my

best regards.

\.

\‘i
5

u

‘\

\\

Sinceréﬁy yours,

Max

Fink, M.D.

1969

�</text>
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