http://exhibits.library.stonybrook.edu/mfp/files/original/b6b69c11ebea4bd2c9f3d5ca3cb211f6.pdf 1868e37aa053bb1245d713516f2b0be1 PDF Text Text -..-wwnwrw—nvw—w—W—T—wwm—mrm.w.-W~WW—n_wm V—w«_r~___.—,v._.._,_.~._t April 28. v..___ -w__em. .V. . v..e.,e.-_r.q__ .______... ,V.___, fer. 1969 Dr. Walter Modell. Editor Pharmacology and Therapeutics Cornell University Medical College 1300 York Avenue New York, New York 10021 Clinical Dear Dr. Modell: Many thanks for the careful review and criticism of our report “Clinical Antidepressant Activity of Cyclazocine - A Narcotic Antagonist“. we have adopted the specific suggestions. which have materially improved the presentation. It is difficult to respond to comments of redundancy and our inadequacy. Redundancy has been reduced. but we are reporting the observations in two studies. with different populations, dosages. rating scales and personnel. For accuracy, we believe it necessary to report what we know and did. Any additional suggestions would be appreciated. Our inadequacies are well known to us. Cyclazocine is useful in treating opiate addiction. an illness with limited economic interest to the pharmaceutical industry. He suggested trials as an antidepressant based on our EEG criteria. They were met with indifference by the representatives of Sterlingwinthrop. Our initial trial was interesting to us but to no one else at NIHH or Sterling-Hinthrop. Recently. Schiele and Abuzzahab have undertaken a similar study. we carried out a second trial in a mental health clinic. Such 0P0 studies were new to me. and we found the drop-out rate high. At first we thought this related to cyclazocine, but we found similar drop-out rates with other drugs and populations in the same clinic. , V ,, w, 77‘-.._,._,,V,._ «WV, fl ,, , , , �VFW—.WWWW “v" WW, ———.—..p -2- Dr. "Odell April 28, 1969 pilot study data. reported here. was sufficiently interesting for us to propose a direct. random assignment study against inipranine. But we could not support this stud . and while we vacillatad. the IND was withdrawn by To out a definitive study. would The Star ing-Hinthrop. carry require our own IND. new innds. 355, But. we believe cyclazocine to be as active . as imipraeine. Should this not be reported - an antidepressant somewhere, somehow? Incidentally. the naloxone studies have been re-instituted (in part because of the report published in OPT) and the pilot studies now include single daily dosages to 1500 age with antagonistic activity observed to l8 hours against 50 mg intravenous heroin. I do not know observations. It Thank you if CPT is still interested in the cyclazocine - without prejudice. if unacceptable. is enclosed for your consideration and patience. Sincerely yours. Fink. H.D. Professor of Psychiatry Max fokp � Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Correspondence Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Correspondence to: Modell, Walter Type The nature or genre of the resource Text Identifier An unambiguous reference to the resource within a given context mfp-05-00-023-2-104 Date A point or period of time associated with an event in the lifecycle of the resource 1969 Creator An entity primarily responsible for making the resource <a title="Fink, Max, 1923-" href="http://id.loc.gov/authorities/names/n79039548" target="_blank">Fink, Max, 1923-</a> Subject The topic of the resource Correspondence -- Correspondence Relation A related resource The Max Fink Collection Description An account of the resource Rights Information about rights held in and over the resource <a title="IN COPYRIGHT - EDUCATIONAL USE PERMITTED" href="http://rightsstatements.org/vocab/InC-EDU/1.0/" target="_blank">IN COPYRIGHT - EDUCATIONAL USE PERMITTED</a> Source A related resource from which the described resource is derived Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York). Language A language of the resource en-US Format The file format, physical medium, or dimensions of the resource application/pdf Publisher An entity responsible for making the resource available Contributor An entity responsible for making contributions to the resource Correspondence