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:—

c-y.

a

r »-...,:-.....,s.

..,x..._..,W~,.H,

January 22, l969
Dr. Philip A. Boyer, Jr.
Meoical Director
Marion Laboratories, Inc.
ioaau Bunker Ridge Road
Kansas tity, Hissoori 64l37

hear hr. boyer.

‘

Thank you very much for the reprints describing studies
of orugs in hyperkinetic children. I-did find the articles
interesting and have sent them to ”W associate, Dr. SimeOn.

subject of
is unclear.
A few years ago we die administer papaverine in single doses
and were able to show changes in the ttG at a tine when
peripheral blood pressure was altered. This study did not
provide enough data to assure us of the central effects of
papaverine. There have been nuncrous studies of the effect
effects of vasooilators
increasing interest, but one for
The

on EEG

is

a

which the oata

of carbon dioxioe on ttﬁ, but these were done primarily using
visual analysis and here too the data is unsatisfactory.

investigator, John Whittier, has been interested
effects with vasodilators but his techniques are
in the
and
his studies should be replicated.
limited
The substance of these remarks is to indicate that while
the demonstration of EEG effects of vasodilators is not complete,
I believe that vasooilators will effect the Etc and that
quantitative methods could describe the changes.
Again, aw thanks for the reprints.
one

EEG

Sincerely‘yours,

Max

Fink,

M.D.

Professor of Psychiatry

MF:kp

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