http://exhibits.library.stonybrook.edu/mfp/files/original/90cbf0ef2fecb1d2f8f4d50ed2e2e274.pdf 69d4884410e5a3dedd1e0f6020e642af PDF Text Text January 25, 1969 Dr. Edgar Grunewald Geigy Pharmaceuticals Ardsley, Dear New York ldbdz to, Following your request, we have reviewed our ongoing ketimipramine~ieipramine study. This second phase was under» taken to compare the two compounds in a random assignnent, blind basis following the peeliminary study (Sunnery II: 8-30-65) and the protocol (3—20—63). The study began in April lees. To date, 26 patients in the outapatient population of the Metropolitan Hospital Community Mental Health Center satisfied the criterion for admission to the study of exhibiting symptoms of depression, retardation and endogenous features. Of these, 6 are classifieo as psychotic depressions; l7 as neurotic depressions and 3 as schizo~affective disorders with depressive symptoms. Fourteen patients were assigned to imipramine and l2 to ketimipramine. Twelve are in progress now. Of l4 subjects, 6 completed the study period and a were twaa—nv : L , incomplete (“drop—out“). The “drop~outs“ were with both drugs to drug factors. 0f 3 ketimipramine treated patients each improved and were discharged from the and appear unrelated clinic. after 5 One of the drop—out patients discontinued treatment weeks therapy, and we have not been able to obtain a follow—up. At her last visit, her symptoms were ameliorated. ' Three patients completed the imipramine much improved (2) and improved (l); rated as trial, being Secondary effects were few (excluoiny the possibility that sone patients failed to return because of symptoms assuneo to be drug related). hith imipramine, headaches and “burning, red eyes“ (l) and nausea (l) were reported. With ketimipramine, ‘ �January 25, 1969 Dr. Edgar Grunewald Geigy Pharmaceuticals Ardsley, Dear New York ldbdz to, Following your request, we have reviewed our ongoing ketimipramine~ieipramine study. This second phase was under» taken to compare the two compounds in a random assignnent, blind basis following the peeliminary study (Sunnery II: 8-30-65) and the protocol (3—20—63). The study began in April lees. To date, 26 patients in the outapatient population of the Metropolitan Hospital Community Mental Health Center satisfied the criterion for admission to the study of exhibiting symptoms of depression, retardation and endogenous features. Of these, 6 are classifieo as psychotic depressions; l7 as neurotic depressions and 3 as schizo~affective disorders with depressive symptoms. Fourteen patients were assigned to imipramine and l2 to ketimipramine. Twelve are in progress now. Of l4 subjects, 6 completed the study period and a were twaa—nv : L , incomplete (“drop—out“). The “drop~outs“ were with both drugs to drug factors. 0f 3 ketimipramine treated patients each improved and were discharged from the and appear unrelated clinic. after 5 One of the drop—out patients discontinued treatment weeks therapy, and we have not been able to obtain a follow—up. At her last visit, her symptoms were ameliorated. ' Three patients completed the imipramine much improved (2) and improved (l); rated as trial, being Secondary effects were few (excluoiny the possibility that sone patients failed to return because of symptoms assuneo to be drug related). hith imipramine, headaches and “burning, red eyes“ (l) and nausea (l) were reported. With ketimipramine, ‘ � Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Correspondence Text A resource consisting primarily of words for reading. 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Title A name given to the resource Correspondence to: Grunewald, Edgar Type The nature or genre of the resource Text Identifier An unambiguous reference to the resource within a given context mfp-05-00-023-1-062 Date A point or period of time associated with an event in the lifecycle of the resource 1969 Creator An entity primarily responsible for making the resource <a title="Fink, Max, 1923-" href="http://id.loc.gov/authorities/names/n79039548" target="_blank">Fink, Max, 1923-</a> Subject The topic of the resource Correspondence -- Correspondence Relation A related resource The Max Fink Collection Description An account of the resource Rights Information about rights held in and over the resource <a title="IN COPYRIGHT - EDUCATIONAL USE PERMITTED" href="http://rightsstatements.org/vocab/InC-EDU/1.0/" target="_blank">IN COPYRIGHT - EDUCATIONAL USE PERMITTED</a> Source A related resource from which the described resource is derived Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York). Language A language of the resource en-US Format The file format, physical medium, or dimensions of the resource application/pdf Publisher An entity responsible for making the resource available Contributor An entity responsible for making contributions to the resource Correspondence