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                  <text>November

7. l968

Dr. Doris H. Clouet

Associate Research Scientist
New York

State Research Institute

Ward's Island.

New

York l0035

Dear Doris.
Thank you very much for the invitation toxnrticipate
in your volume “Biochemistry of Addiction“.l I have discussed
the outline with my associates and would like to share some

of our

comments with you.

of
suggestion of a description of the clinical use
basic
to
heavily
volume
dedicated
narcotic antagonists in a
science aspects is commendable. but one that will contribute
volume. In part. we fear that such a
little to the beoverall since
the majority of readers will be
lost
chapter will
basic scientists.
In reading the list of titles. it seems to us that a
experiments
chapter on the neurophysiology of heroin. andandournaloxone;
on its antagonism to methadone, cyclazocine
and indeed, the experiences and potential usefulness of a
heroin challenge test might be a more useful section. ESpecially,
in the volume as part of Section V.
if it were introduced
Such a chapter could fall in Section IX.
He would prepose to participate in this volume by providing
how
a chapter on our neurophysiological studies. I am not sure
with
weighted
such date, especially since it would be heavily
EEG figures. would be interpreted by biochemists reading the
volume, but I am optimistic that the next few years may bring
to the biochemical
forth some theories of the relation of EEG changes
data
may be usefully
When that occurs. our
changes of the brain.
interpreted by chemists.
The

overall picture
If this suggestion is not consistent with your evaluation
of
of the volume, and you still would like a clinical
summary
an up-to-date
the antagonists. we will be able to provide would
I
like to invite
As
co-contributors.
in the early spring.
M.
Freedman.
Dr. Arthur Zaks and Dr. Alfred

�November

7. l968

Dr. Doris H. Clouet

Associate Research Scientist
New York

State Research Institute

Ward's Island.

New

York l0035

Dear Doris.
Thank you very much for the invitation toxnrticipate
in your volume “Biochemistry of Addiction“.l I have discussed
the outline with my associates and would like to share some

of our

comments with you.

of
suggestion of a description of the clinical use
basic
to
heavily
volume
dedicated
narcotic antagonists in a
science aspects is commendable. but one that will contribute
volume. In part. we fear that such a
little to the beoverall since
the majority of readers will be
lost
chapter will
basic scientists.
In reading the list of titles. it seems to us that a
experiments
chapter on the neurophysiology of heroin. andandournaloxone;
on its antagonism to methadone, cyclazocine
and indeed, the experiences and potential usefulness of a
heroin challenge test might be a more useful section. ESpecially,
in the volume as part of Section V.
if it were introduced
Such a chapter could fall in Section IX.
He would prepose to participate in this volume by providing
how
a chapter on our neurophysiological studies. I am not sure
with
weighted
such date, especially since it would be heavily
EEG figures. would be interpreted by biochemists reading the
volume, but I am optimistic that the next few years may bring
to the biochemical
forth some theories of the relation of EEG changes
data
may be usefully
When that occurs. our
changes of the brain.
interpreted by chemists.
The

overall picture
If this suggestion is not consistent with your evaluation
of
of the volume, and you still would like a clinical
summary
an up-to-date
the antagonists. we will be able to provide would
I
like to invite
As
co-contributors.
in the early spring.
M.
Freedman.
Dr. Arthur Zaks and Dr. Alfred

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