http://exhibits.library.stonybrook.edu/mfp/files/original/8bbd7ee2f98455e1e69a05f63eac6d9b.pdf 65f1b924c7e1fb2d84caa8a5b5534905 PDF Text Text ‘3'. K’Wfl‘rvfiv'v 7"“ zrlw'nf'mmvmmm—menmw w a WWW a“ -= - mi- muwwwwm> saw-m- Vl'mmumisrnmvww ‘K’E’mf:T’WF'W'VJYI'1'5‘7‘WS-WYW‘"‘.'¢W 'A—wfi'. "v- n~»y~m—aw.wm.m November mum- - v-w-r.‘ 4‘ '- - m-v. , =» m a -- ..., » .. w -- 7, l968 Dr. Paul H. Blachly Associate Professor University of Oregon Medical School 3l81 s.w. Sam Jackson Park Road Portland, Oregon 97201 Dear Paul, As is typical for this time of the year, there are many studies under way. The naloxone study was begun again and we have recently given as much as 600 mg a day. Protection against intravenous heroin seems to last, at this dose at least eighteen hours. we have continued to explore the methadone in of blocking intravenous heroin and find efficacy that at lOO mg per day, the subjects do not obtain a euphoric response for up to 75 mg heroin. at least for eighteen hours after a dose; and ford‘bm’g for at least 36 hours. In parallel fashion duration of methadone using this criterion is longer anticipated, and we are continuing to explore the duration and dose response. Nevertheless. one of my staff has preposed a study of acetyl-methadol. With our present methods and experience. we should be equipped to assess the relative merit of methadone and acetyl—methadol, not only on the clinical syndrome of addiction, but in the heroin challenge than The we criterion as well. Before progressing with the details of a protocol, do think that supplies of acetyl-methadol may be available you and in what relative quantity? If the supply is very limited, as I think it might be, then we would suggest a simple heroin challenge study in some subjects in whom we have already determined the duration of effect of methadone. Our present detail studies of methadone should be completed by the end of the year and we could undertake a comparison realistic for us study in January or early February. Is Would be worthwhile to continue this exploration? if the it it supplies are indeed limited to ask supplies available? NIMH to make additional .ve'x My www- best regards. uni-re Sincerely yours, mmavww Fink, “.0. Professor of Psychiatry Max "-a', wan-M‘mmn‘ n Mszp r... w «- r- ~» - -~ ~ ;, - . , . .. v . . ma -- » � Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Correspondence Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Correspondence to: Blachly, Paul Type The nature or genre of the resource Text Identifier An unambiguous reference to the resource within a given context mfp-05-00-022-6-625 Date A point or period of time associated with an event in the lifecycle of the resource 1968 Creator An entity primarily responsible for making the resource <a title="Fink, Max, 1923-" href="http://id.loc.gov/authorities/names/n79039548" target="_blank">Fink, Max, 1923-</a> Subject The topic of the resource Correspondence -- Correspondence Relation A related resource The Max Fink Collection Description An account of the resource Rights Information about rights held in and over the resource <a title="IN COPYRIGHT - EDUCATIONAL USE PERMITTED" href="http://rightsstatements.org/vocab/InC-EDU/1.0/" target="_blank">IN COPYRIGHT - EDUCATIONAL USE PERMITTED</a> Source A related resource from which the described resource is derived Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York). Language A language of the resource en-US Format The file format, physical medium, or dimensions of the resource application/pdf Publisher An entity responsible for making the resource available Contributor An entity responsible for making contributions to the resource Correspondence