http://exhibits.library.stonybrook.edu/mfp/files/original/a9efd23b17ee97cf9ee0f5fe6c87e109.pdf d08cc59f9b49813f6fc0b6e4c4f691a4 PDF Text Text November 7. 1968 Dr. Pau1 H. B1ach1y Associate Professor University of Oregon Medica1 School 3181 S.H. Sam Jackson Park Road 97201 Port1and, Oregon Dear Pau1 . As is typica1 for this time of the year. there are studies under many The naioxone study was begun again and we have recent1y given as much as 600 mg a day. Protection against antravenous heroin seems to 1ast, at this dose at least eighteen way. ours. In para11e1 fashion we have continued to expiore the efficacy of methadone in b1ocking intravenous heroin and find that at 100 mg per day. the subjects do not obtain a euphoric response for up to 75 -heroin. at 1east for eighteen hours after a dose; and for- mg for at 1east 36 hours. The duration of methadone using this criterion is 1onger than we anticipated. and we are continuing to exp1ore the duration and dose response. Neverthe1ess. one of my staff has proposed a study of acetyi-nethadoi. Hith our present methods and experience. we shou1d be equipped to assess the re1ative merit of methadone and acety1~methado1. not only on the c1inica1 syndrome of addiction. out in the heroin cha11enge criterion as ue11. Before progressing with the detai1s of a protoco1. do think that suppiies of acetyi-nethado1 may be avai1ab1e you and in what re1ative quantity? If the supp1y is very 1imited. as I think it might be. then we wouid suggest a simp1e heroin cha11enge study in some subjects in when we have aiready determined the duration of effect of methadone. Our present detai1 studies of methadone shouid be comp1eted by the end of the year and we cou1d undertake a comparison study in January or ear1y February. Is realistic for us to continue this expioration? supp1ies are indeed 1imited to ask supp1ies avai1al1e? My it be worthwhi1e if it NIMH make Hou1d to the additiona1 best regards. Sincere1y yours. Fink, M.0. Professor of Psychiatry Max , w NF:kp � Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Correspondence Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Correspondence to: Blachly, Paul Type The nature or genre of the resource Text Identifier An unambiguous reference to the resource within a given context mfp-05-00-022-6-624 Date A point or period of time associated with an event in the lifecycle of the resource 1968 Creator An entity primarily responsible for making the resource <a title="Fink, Max, 1923-" href="http://id.loc.gov/authorities/names/n79039548" target="_blank">Fink, Max, 1923-</a> Subject The topic of the resource Correspondence -- Correspondence Relation A related resource The Max Fink Collection Description An account of the resource Rights Information about rights held in and over the resource <a title="IN COPYRIGHT - EDUCATIONAL USE PERMITTED" href="http://rightsstatements.org/vocab/InC-EDU/1.0/" target="_blank">IN COPYRIGHT - EDUCATIONAL USE PERMITTED</a> Source A related resource from which the described resource is derived Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York). Language A language of the resource en-US Format The file format, physical medium, or dimensions of the resource application/pdf Publisher An entity responsible for making the resource available Contributor An entity responsible for making contributions to the resource Correspondence