http://exhibits.library.stonybrook.edu/mfp/files/original/cda77447218e13339f280bf130350184.pdf 23afb1106eb91f27a350b4ac19251015 PDF Text Text November 29, 1968 Dr. Thomas V. Ksicher, M.D. Geigy Pharmaceuticals Ardslcy, New York last Dr. Koichct, I hsvs read the material submittcd regarding GP 41299 with bclicvs that we can participate in a number of studies interact, consistont with your goals of establishing tho potsncy and clinical safety of this compound as a hypnotic and/or a minor tranquillizcr. As we review the available dots. the compound hss been touted primarily as a hypnotic and no effort is described to ascertain its other possible and activities. like to Thres types of studies are suggested, and whilc one would rcccumcnd each of then, neither time not personnel would permit this to he demo. 1. EEG profils analysis: The EEG available stuff profile of GP 41299 can in volunteer subjects, on single oral trials. and the spectra can be compared to a standard sedative (snobsrbitsl or diatopcm) and to other compounds as imipramino. fsnflursminc sod chlorpromszfinc. to ascertain its clinical similarity to thesc agents at the dosages tested. be soscsscd 2. Comparison with chlordistopoxido in the therapy of clinical anxiety: The use of ODE as a standard in s mantcl health clinic population has become accepted, and as hsvs undertaken studios of other minor tranquillizsrs in comparison with this compound. A similar study of GP 41299 should be considorsd. 3. Soporific activity in opiate withdrawal: Patients withdrawn from opiates with methadone complain of severe insomnia. The standard procedure is to ndoinistsr oothyprylou (Rolodex) and this is generally acceptable. we would suggest the direct comoariscn of mothyptylon and GP 41299 in a random sequoncs, for 3~S nights. Acceptance by this population would icdiccts s high dcgrcc of soporific activity. would be pleased to undertskc any of those studies, with study as the most profitable for you «w the study that may add materially to your analysis of this novel compound. May I suggest that you call my office and visit with on on December 10-12, December 16 or December 23. Unfortunstcly, I will be out of my office at the other timss in the next tow weeks. the We EEG �u "Jaw-'34” Vrvw' "r m‘-g—-,-‘-. «wmwamxmw—v- Kaichar, Gutsy '7 Thank you ..- w ,-. information. November 29, 1968 for the opportunity of tevicwing this interesting N—'r"mp~a-'..d Sincarely yours, “flit-3’1 www—w- s ""25: r." ea)" Fink, M.D. Frofeusor af Psyehiatty Max v v.» - mil In ch¢ sweat that an EEG study is of intfltiflt, I would also recannnnd that parallal atudiau be undertaken ta determine the affects of GP 41299 on the 'alaap«print' -« the eomputer analysis of the allwnight sleep E36. Tia techniquas available in this country provide more quantitative information than reflected in the summary from Dr. Carma, ané allow a more definitiva claauificgcion of I ate compound and its coapnrison with established alaepvproducing agonca in quantitativn terms. P.8. - v up" m" "w ~ w- ~— r; rrw—Ivz-wm'r-w—v « V... F"; «- SW'WFMF" J .sv—n Km” mnwrmflwrmwawwv vwmqmvmnwfll" "Ha � Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Correspondence Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Correspondence to: Kaicher, Thomas V. Type The nature or genre of the resource Text Identifier An unambiguous reference to the resource within a given context mfp-05-00-022-6-598 Date A point or period of time associated with an event in the lifecycle of the resource 1968 Creator An entity primarily responsible for making the resource <a title="Fink, Max, 1923-" href="http://id.loc.gov/authorities/names/n79039548" target="_blank">Fink, Max, 1923-</a> Subject The topic of the resource Correspondence -- Correspondence Relation A related resource The Max Fink Collection Description An account of the resource Rights Information about rights held in and over the resource <a title="IN COPYRIGHT - EDUCATIONAL USE PERMITTED" href="http://rightsstatements.org/vocab/InC-EDU/1.0/" target="_blank">IN COPYRIGHT - EDUCATIONAL USE PERMITTED</a> Source A related resource from which the described resource is derived Special Collections and University Archives, University Libraries. 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