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                  <text>E

t

E

i

December 3, 1968

1

»

i
:
{

Dr. Peter E.

Siegler,

M.D.
Company
Haines and McCallum Streets

The

National Drug

Philadelphia, Pennstlvsnia
Dear Dr.

19144

Siegler:

is a draft protocol for the study of aletamine.
divided into three parts, which are successive
approximations of the analysis of the problem.
Enclosed

It is

The initial EEG trials are designed to test the dose and
time relations of a single dose as it affects the EEG profile.
These trials provide the basis for the definitive classification
trials which are comparative with knoan standards. As soon as
the classification is defined with surety, a clinical study can
be designed and undertaken in the appropriate papulation.

this procedure may be greater than the conventional
open or double-blind clinical trial, it has some distinct
advantages in providing the conventional data as well as the
While

theoretically significant neurophysiological profile.

I will be pleased to have you visit once again to discuss
these proposals in greater detail and wish to thank you for the
opportunity to read this interesting material.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

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