http://exhibits.library.stonybrook.edu/mfp/files/original/063b4460f63d9ca44ec15bef77f25591.pdf a7ff45b574a4f44a9b14e14101fb50ea PDF Text Text iii December 5, l968 Dr. Harvey Tompkins . Chairman. Panel on Neurology and Psychiatry Health Research Council Department of Hospitals l25 North Street New York, New York l0013 hear Dr. Tompkins: The HRC review of the proposal "Methadone in the Treatment of Chronic Active Psychosis" was read. I am taking the opportunity (as the suggestion of Dr. Lehr) to acquaint you with our progeam and the reasons for our interest in this compound. This study is part of an evaluation of centrally active compounds to determine what relations can be defined between drug induced EEG changes and clinical behavior in man. Most commonly used drugs have been assessed (see review) and we are non attempting predictive studies. Examinations of cyclazocine. fenfluramine, thiothixene, and sulthiame have been completed and those of doxepin, nalouone, marijuana, THCs and heroin are in progress. Methadone is widely used in treating opiate dependence. have found no useful reference to its use in psychosis. Methadone evinces EEG characteristics that warrant the prediction that its use will be associated with a sharp reduction in active psychosis. If true. the EEG~behavioral theories will receive We some affirmation; if not true. the theory will require reasseSSment. This project is not a simple clinical evaluation, as the reviewers imply, but a test of this hypothesis. We have carefully justified each experiment (especially this one) to the hepartment Chairman and the Research Committee of the Colbge. is part of an RIMH supported program, “Quantitative Studies in Psychopharmacology” ~ supported since 1962 and in Missouri since l967 in New York. A copy of the relevant EEG The study Human portions of the grant application, as completed in l966, are enclosed. �1 .v.-n .. .. ‘Vfl-VI,~‘PV—--p'-wr-Iu..-vA~l--W~‘~fm:‘ «um.I'm—r . .nu Jr .— . .- . v .v yawn-up” . w .7, i w era... c -- - "an." Dr. Harvey Tompkins The v33? .4. :r‘wwuecvn—lgnvwn'u‘m< wiry; um.“ Win-4 cm‘tw.-. - «:n-“vum— ,w December 5, l968 -2~ rejection of this project, justified by conventional justice neither to the Panel, nor our catechisms does scientific progress, nor the treatment failures who may be helped if the method is successful. I trust the Panel will have an opportunity to review its recommendation. Sincerely yours, Max Fink, M.D. Professor of Psychiatry Mszp cc: .. Dr. David Lehr Dr. Alfred M. Freedman u; u � Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Correspondence Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Correspondence to: Tompkins, Harvey Type The nature or genre of the resource Text Identifier An unambiguous reference to the resource within a given context mfp-05-00-022-6-577 Date A point or period of time associated with an event in the lifecycle of the resource 1968 Creator An entity primarily responsible for making the resource <a title="Fink, Max, 1923-" href="http://id.loc.gov/authorities/names/n79039548" target="_blank">Fink, Max, 1923-</a> Subject The topic of the resource Correspondence -- Correspondence Relation A related resource The Max Fink Collection Description An account of the resource Rights Information about rights held in and over the resource <a title="IN COPYRIGHT - EDUCATIONAL USE PERMITTED" href="http://rightsstatements.org/vocab/InC-EDU/1.0/" target="_blank">IN COPYRIGHT - EDUCATIONAL USE PERMITTED</a> Source A related resource from which the described resource is derived Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York). Language A language of the resource en-US Format The file format, physical medium, or dimensions of the resource application/pdf Publisher An entity responsible for making the resource available Contributor An entity responsible for making contributions to the resource Correspondence