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                  <text>-..

..~

m.

l...

g, i; rm
\k.

min

.M;

{C 0

December 28, 1968
Dear Jack,
Thank you for your letter and I am enclosing some
which may be of interest and some comments. First, however,
about EEG~~ I have no argument with spectral analysis except its
expense for the missions which I have set for myself, i.e. the
measurement of drug induced changes. For these purposes, every study
shows an equivalence for period analytic and power spectral methods-and the period methods, when done carefully, are ever so much less
expensive. At present, I can do either eaeily and do use whichever

articles

lends

itself to the

analysis. For
spectrum.

A8

n

for

problem at bend. For simple drug changes, period
detailed analysis of the faster frequencies, power
LSD.

to answer. Despite

my

This is a very difficult question for me
review of our data, and the report which

indicates that even (or especially) in chronic mentally ill we ran
risk of inducing psychotic episodee; I am also

a significant
aware that in

this group spontaneous psychotic episodes occur fre~
article is enclosed, as in a review from the Canadian
Mediecel Association Journal. This latter is the most complete to
quently.

Our

date.

position is to

tell

young people that experimentation
useful; but also occasionally den~
geroue. That experimentation with mind—altering drugs (and I always
tell them of the EEG patterns of these drugs) is probably the most
exciting experience possible, but also one that has risks (which
are usually described) and that the best experiments are done under
conditions where control is possible, i.e., n laboratory. I have
offered some the use of the laboratory and the drugs themselves, and
have had afew takers. Another risk in the fact that the supplies on
the street are often impure and ndultercted. I tell them about the
heroin supplies which we get free the FEE and which have recently
been 80% 'pure'; of the THC samples that were amphetamine and ecopolemine;
add of the LSD that was ecopolemine (each analysis in ourbleboratoriee).
my own

is always exciting

and frequently

The most difficult problem
more like alcohol and less

is the question of marijuana,

like

which

is

in probably safe even in large
doses; in non-addicting in the usual sense. and surely less so than
nicotine and alcohol. Our community is psychotic about this drug,
LSD;

�-3and the

irrational approach has clouded the probable real risks of

the other hallucinogens.

Perhaps the greatest approach may be to agree with the
students that their futures, if males, is indeed bleak so long as the
war continues; and that escapism is a normal approach and desire; and
that various escapes are possible—~ hermits and other isolation
devices; drugs and other temporary mind-clouders; emigration; or
identification with a problem or mission in which the sense of
participation and 'being with it' may be more satisfying than any
of the withdrawal defenses. The team roles and the gratifications
have been

also useful.

In answering such questions (and I have frequently) I am
: and tell us
not embarrasses by the question of 'Why do you
that it is bad for us?’ since I have tried all the drugs and dd not
use any now; and when the question of alcohol, smoking, barbiturates
or amphetamines come up—— it is easy to state that these are not
useful when other devices of adaptation suffice. The biggest question
in students is the difference between their parental or teacher's

statements and actions.

How useful these approaches are will not be known. The
kick has stopped in New York and the incidence of admissions to
hospitals have dropped significantly. In large part, this is the
result of the (mistaken, I believe) notion that LSD is specifically
dangerous to genes. The eveidence does not convince me and I do not
use this 'scare' other than to remind the questioners that there
are many effects of drugs that we are unaware of—~and tell them of
the interesting studies of thalidomide and pregnancy.

LSD

These ideas should be sufficient for the present. In view of
the possible additional help, I am enclosing a nre~print of a study
of hallucinogens that I completed last year for the ACNP and which
will be in press in the spring. This describes the central effects
of two large llasses of hallucinogens in man and has been useful in

docuﬁenting

my

'credentials'.

I am pleased to hear that Fred is working actively. Tell him
that the galley proof of the heroin/EEG article was receved this week;
that naloxone is a much weaker antagonist when given orally even at
l Gm/day than methadone (the latter is effective at 100 mgm/day for
48 hours against 50 mgm heroin TV); but that we are continuing the
studies nevertheless.
My

best regards.
Sincerely yours,
Max

Fink,

M.D.

�</text>
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