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Vs

NEW YORK MEDICAL COLLEGE
FLOWER AND FIFTH AVENUE HOSPITALS
FIVE EAST 102ND STREET

NEW YORK, NEW YORK 10029
DEPARTMENT OF PSYCHIATRY

December 28, 1968
Dear Jack,
~~Thank you for your letter and I am enclosing some
articles which may be of interest and some comments. First, however,

about EEG-— I have no argument with spectral analysis except its
expense for the missions which I have set for myself, i.e. the
measurement of drug induced changes. For these purposes, every study

shows an equivalence for period analytic and power spectral methods—and the period methods, when done carefully, are ever so much less
expensive. At present, I can do either easily and do use whichever

lends

itself to the

analysis. For
spectrum.

a

problem at hand. For simple drug changes, period
detailed analysis of the faster frequencies, power

This is a very difficult question for me
review of our data, and the report which
indicates that even (or especially) in shronic mentally ill we ran
a significant risk of inducing psychotic episodes; I am also
aware that in this group spontaneous psychotic episodes occur fre—
quently. Our article is enclosed, as is a review from the Canadian
Mediéhal.Association Journal. This latter is the most complete to
As

for

LSD.

to answer. Despite

my

date.

position is to tell young people that experimentation
is'always exciting and frequently useful; but also occasionally dan—
My own

gerous. That experimentation with mind—altering drugs (and I always
tell them of the EEG patterns of these drugs) is probably the most
exciting experience possible, but also one that has risks (which
are usually described) and that the best experiments are done under
conditions where control is possible, i.e., a laboratory. I have
offered some the use of the laboratory and the drugs themselves, and
have had afew takers. Another risk is the fact that the supplies on
the street are often impure and adulterated. I tell them about the
heroin supplies which we get from the FBN and which have recently
been 80% 'pure'; of the THC samples that were amphetamine and scopolamine;
and of the LSD that was scopolamine (each analysis in our laboratories).
The most difficult problem is the question of marijuana, which is
more like alcohol and less like LSD; is probably safe even in large
doses; is non—addicting in the usual sense, and surely less so than
nicotine and alcohol. Our community is psychotic about this drug,

�-2and the

irrational approach has clouded the probable real risks of

the other hallucinogens.

Perhaps the greatest approach may be to agree with the
students that their futures, if males, is indeed bleak so long as the
war continues; and that escapism is a normal approach and desire; and
that various escapes are possible—— hermits and other isolation
devices; drugs and other temporary mind—clouders; emigration; or
identification with a problem or mission in which the sense of
participation and 'being with it' may be more satisfying than any
of the withdrawal defenses. The team roles and the gratifications
have been also useful.
In answering such questions (and I have frequently) I am
not embarrassesLby the question of 'Why do you
, and tell us
that it is bad for us?'/since I have tried all the drugs and do not
use any now; and when the question of alcohol, smoking, barbiturates
or amphetamines come up—— it is easy to state that these are not
useful when other devices of adaptation suffice. The biggest question
in students is the difference between their parental or teacher's

statements and actions.
How

LSD

2

useful these approaches are will not

be known. The

kick has stopped iﬁ'New York and the incidence of admissions to

hospitals have dropped significantly. In large part, this is the
result of the (mistaken, I believe) notion that LSD is specifically
dangerous to genes. The evgidence does not convince me and I do not
use this 'scare' other than to remind the questioners that there
are many effects of drugs that we are unaware of--and tell them of
the interesting studies of thalidomide and pregnancy.

sufficient for the present. In View of
am
I
the possible additional help,
enclosing a pre-print of a study
of hallucinogens that I completed last year for the ACNP and which
‘will be in press in the spring. This describes the central effects
of two large classes of hallucinogens in man and has been useful in
These ideas should be

documenting

my

'credentials'.

pleased to hear that Fred is working actively. Tell him
that the galley proof of the heroin/EEG article was recéved this week;
that naloxone is a much weaker antagonist when given orally even at
l Gm/day than methadone (the latter is effective at 100 mgm/day for
48 hours against 50 mgm heroin IV); but that we are continuing the
I

am

studies nevertheless.
My

'

best regards.
Sincere

Max

y

Fink,

yours,
M.D.

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