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                  <text>September 24, 1968
Dr. Arnold J. Handell
Department of Psychiatry and Human Behavior
College of Medicine at Irvine

Irvine, California

Dear Dr. Randell:
Thank you for your kind invitation to present a report
of our current electrophysiologic work in relation to psychopathologicsl states. I very much agree with your mission of
honoring Bob Heath for his stimulating work in schizophrenia,
and I would like to participate.

nest relevant problem is the repeated observation of
differences in EEG response to barbiturates (sedation threshold
and pentothsl threshold) among different populations. The 1961
suggestion that unresponsive schizophrenic patients show their
The

lack of response to most psychoactive agents by a lack of response
to injected pentothsl has been under investigation in Missouri and
New York since 1963. The methods of analysis of the EEG have
turned out to be more complex then we first anticipated, so that
the real data available today is still meager. Nevertheless,
if the Program Committee wishes, we would be pleased to review
the problem of responsivity to barbiturates as an index of
dysfunction (altered function) of the central nervous system
in severe psychosis. we can present the recent mathematical
models for responsivity and summarize our recent experiences
in a therapy resistant study in St. Louis.
A

Mbdel

provisional title: Present Status of the Cerebral Reactivity
in Schizophrenia. The report will be written by Dr. Turen Itil

and myself.

Again,

my

thanks for your kind invitation.
Sincerely yours.
Max Fink, M.D.
Professor of Psychiatry

�</text>
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              <text>Correspondence to: Mandell, Arnold J.</text>
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              <text>1968 </text>
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              <text>Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York).</text>
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