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                  <text>rum”

"'mlrv-“wﬂy—arum

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October 9, l968
Dr. Reese T. Jones
Dopartment of Mental Hygiene
The Langley Porter Neuropsychiatric
4Gl Parnassus Avenue
San Francisco, California 94l22

Institute

Dear Reese,

mr—aw

dawn-nwm'

.m—s

Please excuse the delay in answering your letter, but I
that I could handle additional tapes. I believe

had to be sure

that

I can.

1 have read the draft of
your medical student's report
EEG
examined
records carefully. The record of
the
ano
S. Miller showed very little change except in the samples
which follow flashes. But those samples are too short to
be sure.

shows a decrease in alpha abundance
and
an increase in beta and theta activities.
and in amplitude
I read these records before seeing your letter and wonder if
your statement that Shiel's record showed little change may
not have been in error.
The

record of Shiel

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As I

showed you

at the meeting.

we

are prepared to provide

print-outs of the EEG samples. statistical changes if the samples
are sequential. and figures of the EEG changos for each of the
variables analyzed. The analyses can be either of period or
power spectrum.

Trwvw-ﬂv‘uﬁ‘l'

&lt;

wwnpw

.4-

raw-rarw-nvu-

quality of your paper record is excellent and we will
“artefact” the saMplos during playback. Assuming that you will
provide multiple drug administrations in the same subject and
that you will randomly assign the sequence to take care of
the sequence effect. and. ideally that you will throw away
the first records in each subject. I would ask that there be
a 2 minute sine wave followed by a minimum lo minute resting
record. To maintain a constant state of alertness during this
part of the study. we introduce eye opening every 5 minutes.
The

-

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.

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”.3.—

�D" “"95

-2~

October 9, 1968

Following drug administration. at whatever times you
feel the effects are to be measured, we would need a 15 minute
sample done in the same fashion as the pro sample. You may, of
course, record additional 15 minute samples in an experiment
after administration. It may be worth—
at. say, 1 and 2 hours
EEG
while to take an
sample before your interviews. and again,

either after the interview or the flicker experiment.

not know if we can read your tape and would suggest
manufacture
a 10 minute sample with a different frequency
that you
We
read each one and if the frequencies
will
on oath channel.
them
come out as you put
on, then you can proceed. Re are equipped
3
l
back
to play
at 7/8, 3/4. 7 1/2 and 15 ips. Most of our work
1
is at 7/8. I would suggest you record your sample either at
1

this or

do

3 3/&amp;

ips.

that we provide is a “relative“
amplitude. it is important that the calibration signal from an
oscillator go through the EEG and that the settings of the EEG
not be changed thereafter. If you will ”lock“ your calibration
amplitude to some standard, and although it will very, it will
Because the amplitude measure

do so within a narrow range, and thus give you a good amplitude
measure.

for us
itofeasy
the same

to identify samples, we generally
frequency at the end of the experiment
place a signal
1 minute.
then leave a gap of approximately 2 minutes on the
for
tape and begin our next sample with a calibration frequency not
easily related by a factor of 2 to the one before (gég;, 10, 17,
25, 8, 20. £32,).
To make

Incidentally, in reading the medical student's report, it
seems that subject A had no EEG change, D had an intermediate
change and B and C had the greatest EEG change. Hhat were the
behavioral effects Just before and just after the EES samples?
he will begin our THC studies within the next two weeks.
I have not yet received a legal supply of marijuana but plan
to carry out the study anyway. The protocol is being retyped
and I will send you a copy as soon as I have it.

Please send us

a sample

tape and he will proceed from there.
Sincerely yours,
Fink. M.U.
Professor of Psychiatry

Max

MF:kp

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