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                  <text>August 1, 1968
Dr. Francis J. Braceland, Editor
American Journal of Psychiatry

l700 Eighteenth St.. N.W.
Washington, 0.0. 20009
Dear Dr. Braceland:

Enclosed are draft copies of two reports summarizing
our experiences with a narcotic antagonist, cyclazocine.
Following theoretical models which have been of interest
for many years, we found that cyclazocine had a neurophysiological profile similar to imipramine. These clinical

trials, in two different populations,
does indeed have significant clinical

indicate that cyclazocine
antidepressant activity.

We are aware that such open clinical studies are
ordinarily of limited value since enthusiasm may effect the

treatment outcome in depressive populations. But the
demonstration of a significant application of available
neurophysiologic methods provides our incentive to present

this publically.
He

and ask

would appreciate your consideration for publication,
that the two reports be assessed together.

Thank you

for your consideration.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mszp
enc. (2)

�</text>
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              <text>1968 </text>
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