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                  <text>August 5 . l968
Dr. McKeen

Cattell

Department of Pharmacology

Cornell University Medical College
l300 York Avenue

New

York. New York l002l

Dear Dr.

Cattell:

I have read and
and Hyams. and find

re-read the enclosed article

it

for publication in its

by Superman

too complex and unfocussed to be suitable
present form.

The authors approach two separate issues - a new mathematical
approach to the analysis of the integrated amplitude EEG. and the
effects of a novel agent. adrenochrome semicarbazone. The
evaluation of this compound is confused by the authors' interest
in the adrenochrome theory of schizophrenia and their observations

that the integrated EEG of schizophrenics is
reaction than like normal EEG.

much

The

article lacks clarity in the

effort could

I follow the

text.

more

like the

LSD

mathematics and only with
The

results presented are
is focussed on

only the mathematical data. but the discussion

the significance of the data for chronic schizophrenia. The
authors suggest that they have additional normal data (to be
published elsewhere) and use it in their argument. but we do
not have the opportunity to examine the data to learn its relevance
to a comparison with chronic schizophrenia (i.e., age, social class,
diet, previous drug history, educational level, etc, of the normal
population).

Finally. the authors fail to present any simple description
of the effects of the drug on the EEG. In view of the importance
of EEG changes for the effectscf psychoactive drugs, it is a
serious omission to find no simple quantitative description of
pattern and frequency effects, activation effects, egg, in an

article entitled as this one is.
I trust these comments are helpful.

Sincerely yours.

J/ézij7/J
nax Fi’nk,

no.

Professor of Psychiatry

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              <text>Correspondence to: Cattell, McKeen</text>
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              <text>1968 </text>
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              <text>Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York).</text>
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