http://exhibits.library.stonybrook.edu/mfp/files/original/f23d8734fb9a139f10f81bb7e597644f.pdf ff21b683df00b8fe0fc1c5e3db094cd5 PDF Text Text August 6, 1968 Dr. Gaston~Germain Trigos Wyeth Laboratories Box 8299 Philadelphia, Pennsylvania 19101 Dear Dr. Trigos: It was a pleasure to discuss studies of WT 3263 and WY 4036. have had the opportunity to review the data submitted and believe we can contribute to your study program. we 4036. These initial reports of this novel compound report anti-anxiety and anti-convulsant properties. Host unusual is the report of annesic properties in patients. NY of I reviewed the available its EEG data, seeking a better definition neurophysiology. Motor activity in mice was suppressed, with WY 4036 being 100.200 x as effective as chlordiazepoxide. The EEG activity in cats showed a "decreased frequency and further spindling" at intravenous doses of l walks to 4 ng/kg. It is reported an exceptional anticonvulsant, particularly against metrazole. The clinical data reports ataxia and sedation during administration of 5-10 mg/day oral, and nervousness, insomnia, diarrhea or constipation two to three days after cessation of HY 6036. Two studies are suggested in the population available in these laboratories. 1. EEG Profile. As indicated, we find the EEG profile in volunteers, supported by'similar data in patients useful in classifying new psychoactive drugs, and identifying target populations. If a parenteral form of WY 4036 is available, an EEG profile study can be done rapidly, and a suggested protocol is enclosed. If only oral form is available, a similar study it requires more extensive material and a longer period of study. The protocol indicates the differences in design in the supplement. can be done but an �‘i -2~ Dr. Trigos Clinical August 6, 1968 trial. The anti-anxiety activity of tested in a wide variety of anxiety subjects. Our ongoing studies of anti—anxiety agents in a mental health clinic population permit the introduction of WY 4036 in either an open study or a random comparison with chlordissepoxide (our present standard). 2. WY 4036 should properly be I would also suggest that a study of the sedative 4036, especially its effects on the sleep EEG ("sleep—prints") be considered. The data cannot be collected in my laboratories, but we are uniquely equipped to analyze data recorded carefully elsewhere. The date can be collected in collaborating laboratories, and if this is of interest, I will be glad to provide the details. effects of WY — WY 3263. The extensive trials already completed are clear and the new efforts that may be necessary for a better delineation of clinical applications may come best from the extensive clinical trials when the iprindole is released. The data does not include reports of EEG examinations. These would be useful to define the neurophysiologic basis of the clinical response. In the face<ftthe extensive clinical data, perhaps such data would only satisfy outflw scientific fancy. An EEG may yet be useful in completing the be assessed in a fashion similar to can so, profile study submission, and if that suggested in the protocol for WY 4036. protocols are enclosed, for an EEG profile analysis and WY 4036. Protocols for a sleep-print EEG WY EEG 4036 and of an study profile of WY 3263 will be provided. Two a clinical trial of Thank you material. for the opportunity of reading this interesting Sincerely yours, Fink, M.D. Professor of Psychiatry Max MF:kp � Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Correspondence Text A resource consisting primarily of words for reading. 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