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                  <text>August 6. 1968
Dr. Lee Gordon
Hoffmann-La Roche. Inc.
Nutiey, New Jersey 07110
Dear Dr. Gordon:
Mr. Heisman was kind enough to approach us regarding a
high dose Librium study. As you may recognize such a study

does not stimu1ate much interest in the treating physicians
since they have a ready accepted high doses as a standard.
As this has been the first study that Hoffmann-La Roche has
recommended, I regret that we are unab1e to carry
out.

it

Some years ago I undertook phase 3 and phase 4 clinica1
eva1uation studies at Hi11side Hospita1. Nhi1e in Missouri
I found phase 2 and 1ate phase 1 studies of greater interest
and deve10ped, in conjunction with my associates. Drs. Iti1
and Shapiro, a method of EEG anaiysis which we fee1 contributes
to our understanding of the mode of action and target popuiations
for new psychoactive drugs. I am taking the 1iberty of enc1osing
a copy of a review of EEG and drug effects which I prepared for
the ACNP in 1967.

are particuiar1y interested in phase 2 and 1ate phase 1
studies, especia11y those which permit us to utiiize our EEG
mode1. The faci1ities for new drug eva1uation in this Department
are extensive and inc1ude two EEG 1aboratories and a computer
faciiity, a 25 bed in-patient unit for narcotic addicts and
psychotic patients, a 1arge menta1 hea1th c1inic servicing a
wide variety of popu1ations, and 1ate1y a speciai out-patient
unit for chiidren and ldo1escents. It might be useful for you
or some of your associates to visit our faci1ities in order to
obtain an appreciation of the opportunities which they represent.
We

Sincere1y yours,

Max

Fink,

M.D.

Professor of Psychiatry

Mszp
cc:

Mr. H. Heisman

�</text>
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              <text>Correspondence to: Gordon, Lee</text>
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              <text>1968 </text>
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              <text>Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York).</text>
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