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                  <text>T

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F5.

August 8. 1968
Dr. G. B. Biane
Department of Pharmacology

Research Laboratories
Reckitt &amp; Sons, Ltd.

Huii, Engiand

Dear Dr. Biane:
For the past two years we have studied the conditioning
theory of narcotic addiction as expressed by Wikier. We started
with cyciazocine and carried out some studies with naioxone.

Cyciazocine has the disadvantages of a narrow therapeutic
index and naioxone appears to have a very short duration of
action. Despite these iimitations, both treatments appear to
foiiow the deconditioning modei and have shown sufficient promise
to excite us to continue. We are interested, however, in any

other narcotic antagonists

which can be of longer duration of

action and with fewer side effects.
I am

enciosing copies of our reports which wiii bring you

up—to-date in our present program.
.

In the event that SOSO-M, or other active antagonists
goes to human triai, we wouid be anxious to test it.

Sincerely yours,

~_v,ww..wnv,_

Fink, M.D.
Professor of Psychiatry

Max

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