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                  <text>July l0, l968
Dr. Ardie Lubin

Research Psychologist

Navy Medical Neuropsychiatric Research Unit
San Diego, California 92l52

Dear Ardie.

It

was kind

of you to send

me

the preprint of your

effort in discriminating sleep stages. It represents

latest

much work

it, since I have Just
revised the paper of our period analytic approach to the same
problem, following some suggestions from the editors of the
EEG Journal.
The revised version is enclosed and represents much
of the data from the Missouri laboratory. except that there are
additional tables such as you request (page l6) describing the
relation of the computer classification to the visual by the
trained observers. This data is being prepared for another
publication, but I am sending your preprint to Dr. Itil with a
request he share the data with you for inclusion in your report.
and I appreciate the opportunity to read

I am impressed by the portrayal of the power spectral density
approach, especially by the complexity and by the implicit expense.
The difficulties which you describe - difficulties which are described
by others trying this approach, and also found by ourselves
are
the lack of discrimination of small differences in this method
except at a great expense in either time or dollars or both.
—

That PHRS shows good discrimination among sleep stages by
the delta band, the unimportance of theta, the significance of
alpha and sigma, and the difficulties of discriminating stage I
from stage I-REM and stage 3 from stages 2 and 4 are the same
problems and the same discriminators we face in period analysis.
Some additional discrimination: are possible in period analysis,
for the stage 1- stage I-REM discrimination seems now to be
working; the stage 3 discrimination is feasible following your
suggestions (page 18) and some of our own.

�Dr. Lubin

July l0, l968

-2—

conclusions (page l7). Some of the
data is available or is readily
programmable using period analytic and the distance function
I agree with your
recommended additional

approaches.

Perhaps the time has come to compare the available methods

for systematically collected data.

As I indicated earlier, we
to
are prepared
analyze tapes using the period analytic methods.
We would be specially interested if they
are also to be analyzed
by our methods. The costs in dollars and time are negotiable
and should compare favorably with the expense and delays which
you described for your present systems.

Such analyses could be done as part of a demonstration for
an APSS meeting and as the basis for a discussion of the available
methods. If this is not feasible, we would still be willing to
consider a demonstration for you at a cost that is comparable to
that of AstrOpower.

It

was a

My

best regards.

pleasure to hear your report in Washington, and to
Perhaps the enclosed report will permit ou
to be more optimistic about this real-time (or 2-4x real time
analytic system for the reliable and automatic scoring of EEG
sleep stages.
read this preprint.

Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry

MF:kp

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