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                  <text>April 8. 1968
Dr. Fletcher 8. Owen.
A. H. Robins Company
l407 Cummings Drive

Jr.

Richmond, Virginia 23220
Dear

0r.

Owen:

Enclosed are the forms you requested, which I understand
will be filed with the FDA.

patients are confirmed.nercotic addicts with extensive
It is difficult to know whether their reports are more
or less reliable than the.chronic schizophrenics usually studied.
The report by Shelton and-Hollister reflects studies done in
Veteran Administration patients - a group of chronic mentally
ill repeatedly hospitalized and usually inundated with psychoactive drugs. In our patients, we have symptoms reported but
I would not quote these as drug withdrawal until we have studied
Our

drug use.

this further.

These patients who have told us of using narcotics while
taking tybemote report an increase in the “narcotic high.“
do have not observed this ourselves and until we administer
heroin challenges to subjects under our observation, I would
not wish to quote this observation.

Sincerely yours,
Fink, M.D.v
Professor of Psychiatry

Mex

MFtkp

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              <text>1968 </text>
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              <text>Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York).</text>
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