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                  <text>h

April i2. l968
Dr. Carl Salzman
Program Head. ECDEU
Psychophanmacology Research Branch.
5454 Wisconsin Avenue
Chevy Chase, Maryland

NIMH

Dear Dr. Salzman:

recently returned from a visit to Istanbul where
I have monitored our studies of butaperazine and high dose
fluphenazine. The studies are going remarkably well and the
'ease with which the data has been collected has stimulated
me to write to you.
The present climate for new drug studies is becoming
stonny as I and some of the other ECO U workers find the
. I believe there
FDA regulations increasingly restric
H. Denber, Don
ECDEU
as
group
are other members of the
who
have
an interest in international
Gallant and Burt Schiele
be
would
uaeful
to arrange a discussion
studies. Perhaps it
which
representatives of hdustry may
of our experiences to
be invited, so that this avenue of drug evaluation may be
opened. There are problems, for example. the acceptability
I have

of foreign data to the FDA. However. I think the advantages
of this work outweigh the handicaps and a discussion may serve
a useful public purpose.
I look forward

to seeing

you in June.

Sincerely yours,
Fink, ﬂ.D.
Professor of Psychiatry

Max

Hszp
cc:-

Dr.

J. Levine

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