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                  <text>April 30.

1968

Dr. Halter Modell, Editor
Clinical Phanmacology and Therapeutics
Cornell University Medical College
l300 York Avenue
New York, ﬂew York lOOZl
Dear Dr. Hodell:

is a revised copy of our report “Behavioral and
Naloxone in Heroin Dependence.“ The suggestions
of
Studies
and criticisms of the editors were very helpful and we have
considered these comments and included our responses in this
Enclosed

EEG

presentation.

items were not incorporated. The question as to expenae
of naloxone is unanswerable, since Endo Laboratories has consistently
Two

refused to provide a price.

They have indicated

that

stated that
expensive for
naloxone from overseas sources and in this way make
them. and have

it was

too

they might try to obtain

for future research.

it available

other reviewer asked whether the development of physical
dependence on cyclazocine served a useful purpose in discouraging
patients from deliberately missing doses of that drug. he also
asked what is to prevent patients on chronic naloxone from omitting
Your

doses during periods when they plan to use heroin. Physical dependence
to cyclazocine is minimal since the sudden cessation of treatment
results in a withdrawal syndrome of a grippe-like nature. This is
easily tolerated by patients. 80th the cyclazocine and naloxone
subjects omit doses during periods when they plan to use heroin,
but they learn to take their cyclazocine or naloxone soon thereafter
and

this

maneuver seems

to

keep them from becoming readdicted.

lead summary is provided. as suggested. Thank you very
for your cooperation.

A

much

Sincerely yours.
Fink, M.D.
Professor of Psychiatry

Max

Mszp
ENC .

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              <text>Correspondence to: Modell, Walter</text>
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              <text>Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York).</text>
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