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E

Mira-7' ‘

5/

4

W
T0:

Dr. A. h. Freedman

FROM:

Dr.

M.

Fink

DATE:
SUBJECT:

May

l0. l968

Application of Dr. Dinnerstein
for research program on marijuana.

The theoretical problem posed by Dr. Dinnerstein is a
relevant and important one. especially the desire to measure
the effects of marijuana on automobile driving behavior.
This has public health implications as well as some theoretical

value.

The

large -

Drug

slightly

choice of subjects is good but the number seems unusually

250

trials is

a very

large sample.

administration is clear and perhaps might be modified

by drug experience.

test battery is

adequate to the theory. The number of
which these are going to be administered
is probably too large. but I assume Dr. Dinnerstein plans to run
some trials first and then select the most interesting test models.

tests

The

and the time

at

Criticisms: Perhaps the biggest criticism is the comparison
with ethanol for this puts the study on the basis that the ethanol
group was selected for some logical reason. This is not clear in
the text and I do not think the two drugs are either opposed to
each other or are necessarily similar to each other or that the
findings in a comparison bear any necessary relationships to each
other. Because of this comparison group, the number of subjects
.

becomes so
The

large.

section of significance of research leads

that the selection of ethanol or

me

to feel

even the study of cannabis
arises not from the public health interest. but from the popular
enthusiasm for cannabis. I would have thought that a study of
motor performance under cannabis on acute and chronic administration
of cannabis would contribute to our understanding of its physiology
in a shorter time than the proposed study design.
Dr. Dinnerstein does not make clear that he is aware of
the difficulties of obtaining permits to carry out marijuana
research.

�Dr. Freedman

~2-

May

10, l968

It is probable that our own acute and
- Behavioral studies could be significantly amplified
by psychomotor studies such as outlined by Dr. Dinnerstein and
a collaborative study might be considered if the goals were
simply stated.
Recommendation:

chronic

EEG

,

_

Considering the present funding policy of NIH, I think

this application is too large to

be reasonably supported and
the Research Committee might be warranted in recommending a
less anbitious program as an initial experience with marijuana

for this investigator.
MF:kp

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