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                  <text>March

6. 1968

Dr. Joseph G. Bird

Director of Experimental Medicine
Sterling-Winthrop Research Institute
Rensselaer, New York 12144
Dear

Joe,

The question of withdrawal symptoms upon discontinuation
of cyclazocine after extended use was discussed in the reports
published in the J.A.M.A. and to appear in the American Journal
of Psychiatry. Y3§~ﬁay recall that a variety of symptoms were
recorded by the patients upon acute withdrawal. These included
increased irritability, headaches. suspiciousness. depression.

a'hrippe-like” syndrome. The sy-ptoms persisted for one to
three days and were not serious enough to warrant treatment.

and

We concluded that in the usual treatment with
cyclazocine
the termination should be accomplished over a three to five
day period, much in the way the termination of imipramine
treatment is ordinarily concluded.

In those subjects who spontaneously stopped cyclazocine, we
have never had a complaint regarding any significant secondary
e facts.

It has been our impression that the withdrawal symptoms to
cyclazocine are of an order of magnitude and most similar to the
withdrawal symptoms reported for imipramine.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

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              <text>Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York).</text>
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