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                  <text>March

Dr.

Fletcher

A. H.

l8, l968

Owens

Robins Company

1407 Cummings Drive
Richmond 20, Virginia

Dear Dr. Owens:

recent conversation you indicated that the on-going
of
tybamate in the treatment of narcotic addiction, using
study
dosages up to l2 grams daily exceeded the recommendation on the
In our

pncﬁﬁge

'

insert.

As you know, we have already reported on an initial group
of patients with these dosages without problems. You indicated
that a revised IMO is being submitted to the FDA and that this
would be done within the next two weeks.

Insofar as it would raise problems of withdrawal and be
medically contraindicated, the present group of patients will
continue to be treated during these two weeks but we plan not
to add any new patients until the IND has been filed.
Thank you for your cooperation.
Sincerely yours.
Fink, M.D.
Professor of Psychiatry

Max

Mszp

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