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                  <text>35::

v.-

u",
m

vow-

:w
m

«nam-

Y.»nq7;'l«"M"

harch 28, 1968

.4
1'

-

/,.

xvr‘w‘

icw:'.4

men-mm:-

Dr. Michael C. Barry
Assistant Medical Director

'thite

Laboratories. Inc.
New Jersey 07033

Kenilworth,

Dear Dr. Barry:

visit to the Department of
of
Istanbul, where I met our
Psychiatry it the University
examined
some of'the patients receiving fluphenazine.
coworkers and
You may recall that we sent them a supply of fluphenazine concentrate.
A few weeks ago, in order to keep the study going, we sent a
small supply of higher concentrated tablets iron France. I
examined the records and saw 7 patients receiving high dose
fluphenazine.
I have

Just returned

from a

‘

‘

’

-

_

Three of the patients who had

failed to respond to standard

doses of phenothiazines have shown a dramatic improvement with
300 to 500 mg of fluphenazine daily. 0f the 7 patients, 5 had
received between 100 and 600 mg daily, up to l0 days. ~In one

patient

I saw

was ninimum
patient who

extrapyramidal'symptons but in the others. there

rigidity, obvious only on fine testing.
exhibited the most rigidity was part of

series, receiving

30 mg

daily.

I was most impressed

that the very high dose

The one
a low dose

was

safe (in

7 patients) and apparently useful.' Dr. Polvan-and his associates
are continuing, within the limits of the medication available.

this

may soon become available so that
Thank
you very much far your cooperation.
study can continue._
I

trust the concentrate

Sincerely yours.
Fink. M.0.
Professor of Psychiatry

Max

MF:kp

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              <text>Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York).</text>
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