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                  <text>April 23, 1962
James H. Ewing, M.D.

Department of Psychiatry
University of Pennsylvania
Philadelphia h, Pa.
Dear Jim:

I have read your report ”Psychophermecology and
Psychopathology" with considerable interest. Follow—
ing the initial review, your comments on
views of drug activity are cogent. While theoretical
I am impressed by Rubin'e work, as I am by the studies of
Weinstein (one of my teacher's) and Gottschalk, to
whom you refer, each of these authors
emphasize deriv~
of

atives
drug effects distant from their
position (i.e., effects on brain function).theoretical
Thus,
Rubin implies central (brain) drug effects, but
measures
a peripheral effect. Similarly Weinstein and Gottschelk
use speech patterns - also a peripheral brain effect. In
each case, there is need for a more direct measure of
brain function, in addition to this derivative.
We have
also been working on a "neurophysiologic-adaptive" model
and I believe your conclusions to be true.
Many thanks for the opportunity to read this review.
Sincerely yours,
MF:gp

Max

Fin}, M.D.

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              <text>Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York).</text>
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