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                  <text>'V'

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A

December 28, l967
Dr. Charles E. Marshall

Associate Director of

Clinical Research

ninthrop Laboratories

90 Park Avenue
New York, New York l00l6
Dear Dr. Marshall:

Enclosed is a draft copy of a proposed study of oxypertine.
\After reviewing the available literature and discussing the
clinical data with Dr. Hollister, my associates and I would
like to recommend an EEG study. It is our belief, that such
a study will provide data not otherwise available, which may
be most useful in identifying the target populations for this
psychoactive compound.
The

new York Medical Colleoe will be
lose. I
undertake such a study about harch

facilities at the

l,
available to
of
the
University
associates
at
of
my
have
the
assurance
also
when
Missouri who are willing to carry out parallel studies,
they are necessary.

In addition, we would like to consider a clinical study
the
in
population of the Mental Health Clinic, as soon as we
have detennined the EEG profile and made some recommendations
based upon that experience. In that study, we would like to
carry out a procedure similar to that followed in the clinical
evaluation of cyclazocine as an antidepressant.
I would be grateful for your comments. In the interim,
please accept my best wishes for a Prosperous and Happy hen
Year.

Sincerely yours,
Fink, M.0.
Professor of Psychiatry

Max

HF:kp

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