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                  <text>September l8, l967
Dr. Michael C. Barry
Assistant Medical Director

white Laboratories, Inc.
Kenilworth, New Jersey
Dear Dr. Barry:

Both Dr. Itil and I are grateful for your consideration
of our request to undertake a study of fluphenazine in high
dosage in the populations in Istanbul and St. Louis. Your
willingness to file the necessary forms for an IND with the
Food and Drug Administration will be most helpful.
Our estimate of the supplies necessary to undertake th
study in Istanbul is as follows: for 20 patients, l0 weeks
observation at 400 600 mom/day will require 700 gms
fluphenazine. To provide for loss and drop—outs we will
ask a supply of lOOO gms.
—

best form would be in liquid concentrate, at the
palatable concentration, but not less than 20 mgm/cc.
the
concentration
If
is 20 mgm/cc, the amount will be 50 liters.
The

maximum

If tablets are more feasible, then 50 and 100 mgm tablets
should be considered, and the supply requested would be 3000
tablets of 50 mgm and 7000 tablets of l00 mgm.
discussed, we will try to obtain the funds necessary
for this study by diversion from other study programs, but this
source is limited, and we would ask White Laboratories to
consider an additional grant-in-aid in the amount of $l.000.
As we

Thank you

for your consideration.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

cc:

Dr. Itil
Dr. Polvan

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              <text>1967 </text>
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              <text>Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York).</text>
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