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                  <text>June 28, 1957
Dr. Thren M.

Itil

Missouri Institute of Psychiatry
SMOO Arsenal Street
St. Louis, Miesouri63139
.

Dear Turen,

of the anti~anxiety drug protocol relating
to domepin, and a carbon of the letter which I recently sent to
Dean Clyde. You will note that I sent the latest CDT report and
Enclosed

is a

copy

earlier memos regarding

to Dean.
Dr. Cremata called me today to state that the parenteral
form.of doxepin was not yet available and that the protocol will
be filed with the FDA excepting section three on page three and
including the first line of page u. He believes that the parenteral
fcmm will be available soon and would like a revised EEG protocol
from us. If you would like to carry out this
portion of the study,
some

item analyses

would you make up a suggested

protocol.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

enc .

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