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                  <text>June 29, 1967

m. Stanley Yollee, Director
National Institutes of Mental Health
»

Bethesda, Maryland

7

-

Dear 'Dr. Yolles:

report this morning of "A drug more
special interest to me because the data
potent
the piperidyl»
likely that 3?? is one ofJE—BSE.’
presented Was it very
Wee
JB~318
JB—329
or
(Ditran),
benziletes, probably
been
have
and
decade
thm
a
s have been studied for mm
New York Time
than LSD" was of

The

'

in Milwaukee.
'Ihe principal reason for omcludmg that these compounds
the subjects
may be of this class is the clinical description that confusion
excitement,
mania?
experieme a state characterized by
and hallucimtions , misting for days; and that they exhibit
and blurred vision. The
dilated pupils, rapid pulse, dryNewmouth
Times is the exaggeration
York
most witical stetenent in the
of the; psychotic state by ohlozvmzine.
In studies both at Hillside lbspitel and at the Miami
in the Em
Institute of Psychiatry, I have been interested
some years ,
For
.
effects of a. wide Variety of hallucimggens
when
the
my associates and I have jokingly indicated that
foumi
would
be
to
giperidybbenzilatee hit the streets, they

produced by Lakeside Laboratories
.

‘

be mob

more"

potent and

much
The.

LSD, EMT and

differences between the antiand the smethmnﬂmtios are clearly
the liberty
defined by EEG and behavioral criteria. I am taking
1967 from
196C:
and
one
of enclosing; two mports - one from
studies.
vmioh describe the essential parts of these

other smatmmimtics.
'cholinergic halluoixwgene
-

more dangerous than

For practical pxmpoeee, the most important fact is that
(TEA) is a very
an experilmntal conmound, tendiydmamimcrin
the clinical symptoms induced by
potent nntegmiet modifying
90%
of the psychotwimticeractivity.
these companies to 80 ~
studies frm the Lakeside
is available for experimental
M
Laboratories, and I have a supply which has been available to
me mder an IND filed about two years ago.

.

Linn;-

3:“

‘

ﬁ.~.«:.o.-.~:;_;

easnzxeeezaly

�i
mzw‘rfu‘m‘

;rmw.¢~wqm‘

Dr. Yolles

June 29, 1967

«2—

-

7.“.

alerted our staff to the possibility that patients
with
in
acute psyclntic episodes exogenously produced
my com
md will try to modify these states by TEA. Perhaps , if a
supply of 31'? could be made available to us we muld try “to
find volunteers and detarmina specifically whether 31‘? is of
the am class as the piperidyl-benzilates and if , indeed, the
We

&lt;

»
,
-

yum-rm‘am-IWWM;

~
A.

u

have

psychotic state

is mapmaive to

TEA.

Incidentally these studies have been supported largely by
the psychophamaeology Study Cmter of HIM?! under a variety of
study grunts.

Sincemly yours ,
Fink, 24.1).
Professor of Psychiatry

Max

MF:kp
~

.5,

v‘.-:“g.g"j‘-

,
.‘

‘waﬂr

-..u1z:.

shaman-or

74:1-mnnm.ﬂw/

w
a.

.

M.

.,

w

-,
_

v

ll“.

i
mm);

A'Liistﬂt'kiihn'ﬁdr«

u—A

ura-

paw-xmmrvsv

:w

V

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