http://exhibits.library.stonybrook.edu/mfp/files/original/1f692ca8ad7d5c942b39f3171bb29a30.pdf 4b1d75637ae072c681a1f39c8df78a76 PDF Text Text March 9, 1967 Dr. Allen Raskin Research Psychologist Psychoplmmacology Research Branch National Institute of Mental Health Bethesda, Maryland 2001:: Dear Allen, Iwasverypatefulfortheopportunitytcreadthefirst paw, and would report of the collaborative depression study and most interesting like to congratulate you on your clear presentation. It was especially rewarding to find that the clinical efficacy of chlcrprcnezim in depressive disorders was confirmed, for I can clearly recall the difficulties and anxieties with the first Hillside study which appeared to be oontmrytotheprevailingopinions- mtonlyregardingthe treatment of depressith inrespmse toamyththat chlcrpmnazine could induce depressions (1958-59). Your study indicates that the canbination of dflorpmnazine and procyclidim was no more effective in the treatnmt of depression than chlorpmnazine alone and the detailed measures stew that procyclidine was exerting some pharmacological effects. Perhaps we were still under the influence of the state of the art for we tried chlorpmnazine alone in only a few patients, ' fearing that the side effects wmld be too great; and then, the patients tolerated the combination, we were when we found sopleasedthatwemdertookthecanpamtive studyofthe combination against fluipramine. the merits of the culmination were, in part, a response to the often asked question as to whether the efficacy of the coubination in depression may have been due to Our focus on thepmcyclidinealmeaxri, inpart, tothefavorablereports in the literature which appeared to be consistent with out observations. We did treat five patients with procyclidine alone, and discontinued the study for reasons that are unclear to me today. we found �1‘” Dr. Rankin ~2- March 9, 1967 Aslreadycnmmportlmadeafewmtesaxfllslmotl'nse withyouas commute, wtoritioism. ‘ _ MonumtonpageQIogaxdingtl‘nlmincidea-xceofeompymidal reactions with chlorprunazine alone is puzzling. Is it possible that the patients did not get their medication as prescribed, or that antiparkinson medication was made available outside the regular record keeping procedures? 0n occasims, both at hillside and in Miami, such puzzling observations were fumdtobemlatedtoextm—medicalpmcedmsmdtheclinioel factsmmmtsodiscmpentwithourclinioolexperionceasthis observation would imply. Table 3 has most interestim date. The combinatim appears to enhmoe or sustain excitement - an observation consistent with the defined BEG effects of parocyclidine‘; and to enhame drymssofthemrthandblumimofvisim-possiblemleted to the antiornlinergic properties of pmcyolidine. that interesting, Wet, is the clear denmstmtion that adaptetim to the secmdary effects of drowsiness, nasal congestion, blm'red visimamilossofappetitedoesocctm-flmscmfimingmm clinical It is here that the similarities of the combination to the chlor-prunazine slam are so convincing. swim. Inthediswssimwogelmtheopeningpamgmphenlarges foamsesmtmincidehoeofseoondaxyeffects. Theimidenoe ontrnattritionmtecflflforthsactive mumts,m1d mpwmdismttoohigxincowarismtoclinioelexperimoe, mmmoontmststmldbemdemtwithnotmetmnt or with placebo moment but with other accepted ‘matmnts fordepressivedisorderasficrammipzmim. Amtheseside effectsandtheattritionmtedisoomdmtwith that whichwas observedinfixsimipzmimstudy? ‘misaqmasismsyperhaps bemdifiedbyymmsubsequent emerienoe. Mfiming'thetcwdosagermgemsyhavebemtoohigh ismtuwwected,forwehadbeenworkingwithapowlationof finrapyfailmsandhadedjmtedqmdomtobeabovethat neededbyfiOtoftlntestgrow. Sincethen,Ihavefoundthat chlotpmmine dosages of 500 - 800 m are generally adequate. Assimletmethankymfortlwoppommitytomedthis ropes-mendfortmmtlutyoumyedomwrlsssstudyat Hillsideinmfiningmmobsmations. 11001ch with Mantidpetimtofiumtmpmsofflndepmssionsumy. Many themes and my best regards. Sincerely yours, Fink, M.D. Professor of Psychiatry Max Mszp cc: Dr. Jonathan 0. Cole � Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Correspondence Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Correspondence to: Raskin, Allen Type The nature or genre of the resource Text Identifier An unambiguous reference to the resource within a given context mfp-05-00-021-3-123 Date A point or period of time associated with an event in the lifecycle of the resource 1967 Creator An entity primarily responsible for making the resource <a title="Fink, Max, 1923-" href="http://id.loc.gov/authorities/names/n79039548" target="_blank">Fink, Max, 1923-</a> Subject The topic of the resource Correspondence -- Correspondence Relation A related resource The Max Fink Collection Description An account of the resource Rights Information about rights held in and over the resource <a title="IN COPYRIGHT - EDUCATIONAL USE PERMITTED" href="http://rightsstatements.org/vocab/InC-EDU/1.0/" target="_blank">IN COPYRIGHT - EDUCATIONAL USE PERMITTED</a> Source A related resource from which the described resource is derived Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York). Language A language of the resource en-US Format The file format, physical medium, or dimensions of the resource application/pdf Publisher An entity responsible for making the resource available Contributor An entity responsible for making contributions to the resource Correspondence