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                  <text>March 15 , 1967

Dr. Edmund

De

Maar

Associate Director
Departxent of Clinical Pharmacology
Geigy Research

Ardsley,

New

York 10502

DearDr.DeMaar:

I have read the basic data sheet on GPA 1657 with a great
deal of interest. However, some of the information is lacking
which would be helpful in dismssicns with my associates regarding
a proposed study.

Itmuldbehelpfultohaveasmmarycfthe initialhuman
data with Specific reference to dose, secondary effects, and
analgesic activity which may be available in the initial patients
receiving this drug for post-operative pain.
'

You

refer to findings from Lexington that

GPA

1657

acts

both as an agonist and an antagonist in different dosage ranges.
It would be most helpful if sane of the evidence in human subjects
for these statements were made available.

Finally, is there any direct evidence of central nervous

effects, as in EEG data?
If this information is not available in written form, I
would be pleased to arrange to meet with you to discuss what
little information may be in hand.
system

Sincerely yours ,
Fink, M.D.
Professor of Psychiatry

Max

Mszp
cc: Dr. T. P. 8. Watts

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              <text>Correspondence to: De Marr, Edmund</text>
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