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                  <text>0‘.

December 20, 1966

Dr. Alain Sanseigne

The Squibb Institute
Georges Road
New

Brunswick,

New

for Medical Research

Jersey

Dear Alain,
Enclosed is a protocol of our proposed fluphemine
decanoate study in ammlatory psydntic patients at the
New Ymk Medical College - Metropolitan Hospital Medical
Center. A coupleted set of PM forms «md my mimlum
vitae am also enclosed for your files. This protocol
follows our recent discussions closely. Patients receiving

otrmrphencthiszineemfirsttobeu‘ansfmedtooral

fluphenazine and then to intrumscular decenoste. Patients
not receiving phenothiszinee are first to receive oral
fluphenazine and then the intmuusculsr preparation.

Asaomtmlgmuplsterintmstudy, anmnbercf
patients who are doing well on the intamsoular prepmtion
are to continue receiving injections but with the fluphenezine
at 1/100 the dose. By this novel method, I believe we can
obtain some mderstarm of the direct phannaoologicel effects
of ﬂuplwmzine.

Ifthisetudymeetswithymmappmval,wewillhesble

to undertake the first transfers or minismtions of oral
flupl’aemzine about mid—Jetway and the intrumswlar minions-timsearlyinf‘ebmary. Wewillrequirecontinuedmppliespf
omlfluptmzine, fluphmazinedecemate,andabmtApril, a
lwstruxgthfluphenezinedecanoate.

Initially, 200 cc of flnphemzim decmoate at a
25 nag/cc would be useful This could be
wppliedinsmallmlti—pwpcsevioleor2ccanpules,
whichever is available. As for the ﬂupimxazine hydrochloride,
concentration of

Imtetruttmususlprepmtimisasl, 2.5m5ngtablets.
Shmmmplmmingdoesgessveragixghomwmg,canlem
tablets be supplied? If so, an initial supply of 2000 tablets

would be helpful. In addition, a placebo form (1000 tablets)
would provide us with madam:
ﬂexibility in the moment

of our patients.

�H"

g 5,§

Deoanber 20, 1966

'I’hedatatobeprovidedwillincludeslmtcasemies
the fem
will

mquast
clinical laboratory Narration. I
not available
these
are
If
usedbthNIMH-BCDHmegzwm.
and the

wrenthesunyiabegun,mwillcreateourcwnfommdsem1t
towaoryourcmments.
In addition to the supplies of mdicatinn, which
large study will be a‘ significant cmtribution to the
I would request your consideration of a grant—~in-aide
to be made available at the end of the study for data
appropriate case reports and a final evaluation.

I look
My

forward

of $8,000
analysis,

to your cements and to undertaldng this study.

best regards.
Sincerely yours ,
Pink, 3.1).
Professor of Psychiaty

Max

81108 0

for such a

pmgmn,

�</text>
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              <text>Correspondence to: Sanseigne, Alain</text>
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            <elementText elementTextId="26056">
              <text>mfp-05-00-020-8-550</text>
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              <text>1966 </text>
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            <elementText elementTextId="26058">
              <text>&lt;a title="Fink, Max, 1923-" href="http://id.loc.gov/authorities/names/n79039548" target="_blank"&gt;Fink, Max, 1923-&lt;/a&gt;</text>
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              <text>The Max Fink Collection</text>
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            <elementText elementTextId="26062">
              <text>&lt;a title="IN COPYRIGHT - EDUCATIONAL USE PERMITTED" href="http://rightsstatements.org/vocab/InC-EDU/1.0/" target="_blank"&gt;IN COPYRIGHT - EDUCATIONAL USE PERMITTED&lt;/a&gt;</text>
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          <description>A related resource from which the described resource is derived</description>
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            <elementText elementTextId="26063">
              <text>Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York).</text>
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              <text>en-US</text>
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